Differences in cardiovascular risk profile based on relationship between post-load plasma glucose and fasting plasma levels

• Published in: Diabetes/metabolism research and reviews Vol. 25; no. 4; pp. 351 - 356
• Main Authors: Succurro, Elena, Marini, Maria Adelaide, Grembiale, Alessandro, Lugarà, Marina, Andreozzi, Francesco, Sciacqua, Angela, Hribal, Marta Letizia, Lauro, Renato, Perticone, Francesco, Sesti, Giorgio
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.05.2009; Wiley
• Subjects: Adult; atherosclerosis; Atherosclerosis (general aspects, experimental research); Atherosclerosis - blood; Atherosclerosis - complications; Atherosclerosis - physiopathology; Biological and medical sciences; Biomarkers - blood; Blood and lymphatic vessels; Blood Glucose - metabolism; Body Composition; Cardiology. Vascular system; cardiovascular disease; Carotid Arteries - physiopathology; carotid intima-media thickness; Cross-Sectional Studies; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Fasting - blood; Female; Fundamental and applied biological sciences. Psychology; glucose tolerance; Glucose Tolerance Test; Humans; Male; Medical sciences; Middle Aged; Pedigree; Reference Values; Risk Assessment; Vertebrates: endocrinology; Endocrinopathy; Fasting; Diabetes mellitus; Tolerance; Cardiovascular disease; Glucose tolerance test; Glucose; carotid intima-media thickness; Artery; Blood plasma; Vascular disease; Thickness; Blood vessel; Carotid; Atherosclerosis; Risk factor; Cardiovascular risk; Intima; Circulatory system; Vascular wall; glucose tolerance; Fast; Endocrinology; Comparative study
• ISSN: 1520-7552; 1520-7560; 1520-7560
• DOI: 10.1002/dmrr.951

Background It has been shown that subjects with normal glucose tolerance (NGT), whose plasma glucose (PG) levels do not return to their fasting PG level within 2 h during an oral glucose tolerance test (OGTT) (Group I), have a significantly higher risk to develop type 2 diabetes than NGT subjects whose 2‐h glucose returns to, or drops below, the fasting level (Group I). However, it is still unsettled whether individuals in Group II have a more atherogenic profile than Group I subjects. Methods To address this issue, we examined 266 non‐diabetic offspring of type 2 diabetic patients, recruited in the context of EUGENE2 cross‐sectional study. All subjects underwent an euglycaemic‐hyperinsulinemic clamp to assess glucose tolerance and insulin sensitivity. Furthermore, cardiovascular risk factors and ultrasound measurement of carotid intima‐media thickness (IMT) were evaluated. Results Individuals in Group II exhibited significantly higher waist circumference, blood pressure, triglycerides, 2‐h post‐load PG, hsC‐reactive protein, interleukin‐6, insulin‐like growth factor‐1 (IGF‐1), IMT, and lower insulin sensitivity than subjects in Group I. Conclusions Subjects with NGT, whose PG concentration does not return to their fasting PG level within 2 h during OGTT, have an atherogenic profile, suggesting that performing OGTT with measurement of PG every 30 min may be useful to assess the risk for cardiovascular disease in glucose‐tolerant subjects. Copyright © 2009 John Wiley & Sons, Ltd.