Deliverable navigation for multicriteria IMRT treatment planning by combining shared and individual apertures

• Published in: Physics in medicine & biology Vol. 58; no. 21; pp. 7683 - 7697
• Main Authors: Fredriksson, Albin, Bokrantz, Rasmus
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 07.11.2013
• Subjects: Algorithm; Convex Pareto Surfaces; Decomposition; deliverable navigation; Generation; Humans; intensity-modulated radiation therapy; multicriteria optimization; Optimization; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted - methods; Radiotherapy, Intensity-Modulated - methods; Shoot Imrt; Step; step-and-shoot; Therapy; Time Factors
• ISSN: 0031-9155; 1361-6560; 1361-6560
• DOI: 10.1088/0031-9155/58/21/7683

We consider the problem of deliverable Pareto surface navigation for step-and-shoot intensity-modulated radiation therapy. This problem amounts to calculation of a collection of treatment plans with the property that convex combinations of plans are directly deliverable. Previous methods for deliverable navigation impose restrictions on the number of apertures of the individual plans, or require that all treatment plans have identical apertures. We introduce simultaneous direct step-and-shoot optimization of multiple plans subject to constraints that some of the apertures must be identical across all plans. This method generalizes previous methods for deliverable navigation to allow for treatment plans with some apertures from a collective pool and some apertures that are individual. The method can also be used as a post-processing step to previous methods for deliverable navigation in order to improve upon their plans. By applying the method to subsets of plans in the collection representing the Pareto set, we show how it can enable convergence toward the unrestricted (non-navigable) Pareto set where all apertures are individual.