N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects

Patients who had discontinued statins because of side effects received four bottles of a statin, four bottles of placebo, and four empty bottles, each to be used for 1 month in a random sequence for 12 months. The symptom burden with placebo was 90% of the symptom burden with the statin.

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Bibliographic Details
Published inThe New England journal of medicine Vol. 383; no. 22; pp. 2182 - 2184
Main Authors Wood, Frances A, Howard, James P, Finegold, Judith A, Nowbar, Alexandra N, Thompson, David M, Arnold, Ahran D, Rajkumar, Christopher A, Connolly, Susan, Cegla, Jaimini, Stride, Chris, Sever, Peter, Norton, Christine, Thom, Simon A.M, Shun-Shin, Matthew J, Francis, Darrel P
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 26.11.2020
Subjects
Adult
Atorvastatin - adverse effects
Confidence Intervals
Double-Blind Method
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects
Medical research
Placebos - adverse effects
Side effects
Statins
Online AccessGet full text
ISSN0028-4793
1533-4406
1533-4406
DOI10.1056/NEJMc2031173

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Summary:Patients who had discontinued statins because of side effects received four bottles of a statin, four bottles of placebo, and four empty bottles, each to be used for 1 month in a random sequence for 12 months. The symptom burden with placebo was 90% of the symptom burden with the statin.
Bibliography:SourceType-Scholarly Journals-1
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMc2031173