Close association of HLA-B51 in persons with recurrent aphthous stomatitis

• Published in: Oral surgery, oral medicine, oral pathology Vol. 74; no. 4; pp. 455 - 458
• Main Authors: Shohat-Zabarski, R., Kalderon, S., Klein, T., Weinberger, A.
• Format: Journal Article
• Language: English
• Published: Saint Louis, MO Elsevier Inc 01.10.1992; Mosby
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; Dermatology; Family Health; Female; HLA-B Antigens - blood; HLA-B51 Antigen; HLA-C Antigens - blood; Humans; Male; Medical sciences; Middle Aged; Skin involvement in other diseases. Miscellaneous. General aspects; Stomatitis, Aphthous - immunology; Asia; Israel; Human; HLA-System; Skin disease; Nervous system diseases; Stomatology; Recurrent; Behcet syndrome; Oral cavity; Eye disease; Stomatitis; Association; Risk factor; Frequency; ENT disease
• ISSN: 0030-4220; 1878-2175
• DOI: 10.1016/0030-4220(92)90294-Z

The HLA typing profile of 26 Israeli subjects with recurrent aphthous stomatitis (RAS) was examined and compared with that of 100 healthy control subjects. HLA-B51 was found in six subjects (23%) with RAS and in nine control subjects (9%) ( p < 0.05). HLA-Cw7 was found in six subjects with RAS (23%) and in five control subjects (5%) ( p < 0.01). Eleven subjects had first-degree relatives who had RAS. Because a high frequency of HLA-B51 has been found in Behç¸et's syndrome and aphthous stomatitis is part of this syndrome, it is suggested that in some subjects with RAS the entire syndrome may actually develop in the future.