Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

• Published in: Journal of thrombosis and haemostasis Vol. 18; no. 4; pp. 844 - 847
• Main Authors: Tang, Ning, Li, Dengju, Wang, Xiong, Sun, Ziyong
• Format: Journal Article
• Language: English
• Published: England Elsevier Limited 01.04.2020; John Wiley and Sons Inc
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Betacoronavirus; Blood Coagulation; Brief Report; China; coagulation parameter; Coronaviridae; Coronavirus Infections - mortality; Coronavirus Infections - physiopathology; Coronaviruses; COVID-19; Disseminated intravascular coagulation; Disseminated Intravascular Coagulation - mortality; Disseminated Intravascular Coagulation - virology; D‐dimer; Female; Fibrin; fibrin degradation product; Fibrin Fibrinogen Degradation Products - analysis; HAEMOSTASIS; Humans; Male; Middle Aged; novel coronavirus pneumonia; Pandemics; Partial Thromboplastin Time; Pneumonia; Pneumonia, Viral - mortality; Pneumonia, Viral - physiopathology; Prothrombin; Prothrombin Time; Retrospective Studies; SARS-CoV-2; Thromboplastin; Young Adult; China; D-dimer; novel coronavirus pneumonia; fibrin degradation product; coagulation parameter; disseminated intravascular coagulation
• ISSN: 1538-7933; 1538-7836; 1538-7836
• DOI: 10.1111/jth.14768

Background In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronavirus pneumonia (NCP) cases were a concern. Objectives To describe the coagulation feature of patients with NCP. Methods Conventional coagulation results and outcomes of 183 consecutive patients with confirmed NCP in Tongji hospital were retrospectively analyzed. Results The overall mortality was 11.5%, the non‐survivors revealed significantly higher D‐dimer and fibrin degradation product (FDP) levels, longer prothrombin time and activated partial thromboplastin time compared to survivors on admission (P < .05); 71.4% of non‐survivors and 0.6% survivors met the criteria of disseminated intravascular coagulation during their hospital stay. Conclusions The present study shows that abnormal coagulation results, especially markedly elevated D‐dimer and FDP are common in deaths with NCP.