Quantitative Metabolomics to Explore the Role of Plasma Polyamines in Colorectal Cancer
Colorectal cancer (CRC) is one of the major public health and socio-economic problems, which management demands the development of non-invasive screening tests. Assessment of circulating polyamines could be a valuable tool, although analytical problems still preclude its clinical practice. We exploi...
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| Published in | International journal of molecular sciences Vol. 24; no. 1; p. 101 |
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| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
MDPI
21.12.2022
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1422-0067 1661-6596 1422-0067 |
| DOI | 10.3390/ijms24010101 |
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| Abstract | Colorectal cancer (CRC) is one of the major public health and socio-economic problems, which management demands the development of non-invasive screening tests. Assessment of circulating polyamines could be a valuable tool, although analytical problems still preclude its clinical practice. We exploited ultra-high-resolution liquid chromatography and mass spectrometry, as a highly sensitive and innovative method, to profile eleven polyamines, including spermine and spermidine with their acetylated forms. These data together with an evaluation of the inflammatory indexes might represent suitable biomarkers for the identification of CRC patients. The statistical models revealed good discrimination in distinguishing CRC patients from healthy subjects. The plasma assessment of ornithine and acetylspermine, as well as lymphocyte/platelet ratio, revealed helpful information on the progression of CRC. The combined profiles of circulating polyamines and inflammatory indexes, together with the application of an innovative technology, could represent a valuable tool for discriminating patients from different clinical groups. |
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| AbstractList | Colorectal cancer (CRC) is one of the major public health and socio-economic problems, which management demands the development of non-invasive screening tests. Assessment of circulating polyamines could be a valuable tool, although analytical problems still preclude its clinical practice. We exploited ultra-high-resolution liquid chromatography and mass spectrometry, as a highly sensitive and innovative method, to profile eleven polyamines, including spermine and spermidine with their acetylated forms. These data together with an evaluation of the inflammatory indexes might represent suitable biomarkers for the identification of CRC patients. The statistical models revealed good discrimination in distinguishing CRC patients from healthy subjects. The plasma assessment of ornithine and acetylspermine, as well as lymphocyte/platelet ratio, revealed helpful information on the progression of CRC. The combined profiles of circulating polyamines and inflammatory indexes, together with the application of an innovative technology, could represent a valuable tool for discriminating patients from different clinical groups. Colorectal cancer (CRC) is one of the major public health and socio-economic problems, which management demands the development of non-invasive screening tests. Assessment of circulating polyamines could be a valuable tool, although analytical problems still preclude its clinical practice. We exploited ultra-high-resolution liquid chromatography and mass spectrometry, as a highly sensitive and innovative method, to profile eleven polyamines, including spermine and spermidine with their acetylated forms. These data together with an evaluation of the inflammatory indexes might represent suitable biomarkers for the identification of CRC patients. The statistical models revealed good discrimination in distinguishing CRC patients from healthy subjects. The plasma assessment of ornithine and acetylspermine, as well as lymphocyte/platelet ratio, revealed helpful information on the progression of CRC. The combined profiles of circulating polyamines and inflammatory indexes, together with the application of an innovative technology, could represent a valuable tool for discriminating patients from different clinical groups.Colorectal cancer (CRC) is one of the major public health and socio-economic problems, which management demands the development of non-invasive screening tests. Assessment of circulating polyamines could be a valuable tool, although analytical problems still preclude its clinical practice. We exploited ultra-high-resolution liquid chromatography and mass spectrometry, as a highly sensitive and innovative method, to profile eleven polyamines, including spermine and spermidine with their acetylated forms. These data together with an evaluation of the inflammatory indexes might represent suitable biomarkers for the identification of CRC patients. The statistical models revealed good discrimination in distinguishing CRC patients from healthy subjects. The plasma assessment of ornithine and acetylspermine, as well as lymphocyte/platelet ratio, revealed helpful information on the progression of CRC. The combined profiles of circulating polyamines and inflammatory indexes, together with the application of an innovative technology, could represent a valuable tool for discriminating patients from different clinical groups. |
| Author | Culeddu, Nicola Carru, Ciriaco Azara, Emanuela Gigliola Muroni, Maria Rosaria Coradduzza, Donatella De Miglio, Maria Rosaria Scanu, Antonio Mario Angius, Andrea Zinellu, Angelo Rallo, Vincenzo Medici, Serenella Congiargiu, Antonella Arru, Caterina |
| AuthorAffiliation | 5 Department of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, 07100 Sassari, Italy 1 Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy 2 Institute of Biomolecular Chemistry, National Research Council, 07040 Sassari, Italy 6 Control Quality Unit, Azienda-Ospedaliera Universitaria (AOU), 07100 Sassari, Italy 3 Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy 4 Institute for Genetic and Biomedical Research (IRGB), Department of Biomedicine, National Research Council, 09042 Monserrato, Italy |
| AuthorAffiliation_xml | – name: 5 Department of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, 07100 Sassari, Italy – name: 2 Institute of Biomolecular Chemistry, National Research Council, 07040 Sassari, Italy – name: 3 Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy – name: 1 Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy – name: 4 Institute for Genetic and Biomedical Research (IRGB), Department of Biomedicine, National Research Council, 09042 Monserrato, Italy – name: 6 Control Quality Unit, Azienda-Ospedaliera Universitaria (AOU), 07100 Sassari, Italy |
| Author_xml | – sequence: 1 givenname: Donatella surname: Coradduzza fullname: Coradduzza, Donatella – sequence: 2 givenname: Caterina surname: Arru fullname: Arru, Caterina – sequence: 3 givenname: Nicola orcidid: 0000-0001-7432-6415 surname: Culeddu fullname: Culeddu, Nicola – sequence: 4 givenname: Antonella orcidid: 0000-0002-8112-1298 surname: Congiargiu fullname: Congiargiu, Antonella – sequence: 5 givenname: Emanuela Gigliola surname: Azara fullname: Azara, Emanuela Gigliola – sequence: 6 givenname: Antonio Mario orcidid: 0000-0001-7878-1167 surname: Scanu fullname: Scanu, Antonio Mario – sequence: 7 givenname: Angelo orcidid: 0000-0002-8396-0968 surname: Zinellu fullname: Zinellu, Angelo – sequence: 8 givenname: Maria Rosaria surname: Muroni fullname: Muroni, Maria Rosaria – sequence: 9 givenname: Vincenzo orcidid: 0000-0002-8938-5650 surname: Rallo fullname: Rallo, Vincenzo – sequence: 10 givenname: Serenella orcidid: 0000-0002-4304-0251 surname: Medici fullname: Medici, Serenella – sequence: 11 givenname: Ciriaco orcidid: 0000-0002-6985-4907 surname: Carru fullname: Carru, Ciriaco – sequence: 12 givenname: Andrea orcidid: 0000-0003-2596-6461 surname: Angius fullname: Angius, Andrea – sequence: 13 givenname: Maria Rosaria orcidid: 0000-0002-9393-3234 surname: De Miglio fullname: De Miglio, Maria Rosaria |
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| Keywords | polyamine inflammatory indexes colorectal cancer biomarker agmatine |
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