Quantitative Metabolomics to Explore the Role of Plasma Polyamines in Colorectal Cancer

Colorectal cancer (CRC) is one of the major public health and socio-economic problems, which management demands the development of non-invasive screening tests. Assessment of circulating polyamines could be a valuable tool, although analytical problems still preclude its clinical practice. We exploi...

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Published inInternational journal of molecular sciences Vol. 24; no. 1; p. 101
Main Authors Coradduzza, Donatella, Arru, Caterina, Culeddu, Nicola, Congiargiu, Antonella, Azara, Emanuela Gigliola, Scanu, Antonio Mario, Zinellu, Angelo, Muroni, Maria Rosaria, Rallo, Vincenzo, Medici, Serenella, Carru, Ciriaco, Angius, Andrea, De Miglio, Maria Rosaria
Format Journal Article
LanguageEnglish
Published Switzerland MDPI 21.12.2022
Subjects
Chromatography, Liquid - methods
Colorectal Neoplasms - diagnosis
Humans
Polyamines - analysis
Spermidine
Spermine
polyamine
inflammatory indexes
colorectal cancer
biomarker
agmatine
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ISSN1422-0067
1422-0067
DOI10.3390/ijms24010101

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Summary:Colorectal cancer (CRC) is one of the major public health and socio-economic problems, which management demands the development of non-invasive screening tests. Assessment of circulating polyamines could be a valuable tool, although analytical problems still preclude its clinical practice. We exploited ultra-high-resolution liquid chromatography and mass spectrometry, as a highly sensitive and innovative method, to profile eleven polyamines, including spermine and spermidine with their acetylated forms. These data together with an evaluation of the inflammatory indexes might represent suitable biomarkers for the identification of CRC patients. The statistical models revealed good discrimination in distinguishing CRC patients from healthy subjects. The plasma assessment of ornithine and acetylspermine, as well as lymphocyte/platelet ratio, revealed helpful information on the progression of CRC. The combined profiles of circulating polyamines and inflammatory indexes, together with the application of an innovative technology, could represent a valuable tool for discriminating patients from different clinical groups.
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These authors contributed equally to this work.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms24010101