Catechol‐O‐Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta‐Analysis of Previously Published Studies

• Published in: European eating disorders review Vol. 25; no. 6; pp. 524 - 532
• Main Authors: Collantoni, Enrico, Solmi, Marco, Gallicchio, Davide, Santonastaso, Paolo, Meneguzzo, Paolo, Carvalho, Andrè F., Stubbs, Brendon, Clementi, Maurizio, Pinato, Claudia, Forzan, Monica, Cassina, Matteo, Fontana, Francesca, Piva, Ivana, Siani, Roberta, Salvo, Pierandrea, Tenconi, Elena, Veronese, Nicola, Correll, Christoph U., Favaro, Angela
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons, Limited 01.11.2017
• Subjects: Anorexia; anorexia nervosa; Anorexia Nervosa - genetics; Biological Specimen Banks; Bulimia; bulimia nervosa; Bulimia Nervosa - genetics; Case-Control Studies; Catechol O-Methyltransferase - genetics; catechol‐O‐methyltransferase (COMT); Eating disorders; Feeding and Eating Disorders - genetics; Gene Frequency; Genotype; Humans; Meta-analysis; Polymorphism; Polymorphism, Single Nucleotide; Systematic review; Val158Met; bulimia nervosa; Val158Met; polymorphism; anorexia nervosa; catechol-O-methyltransferase (COMT)
• ISSN: 1072-4133; 1099-0968; 1099-0968
• DOI: 10.1002/erv.2555

Objectives We investigated whether catechol‐O‐methyltransferase (COMT) Val158Met polymorphism is associated with eating disorders (EDs). Methods We conducted a systematic literature search of studies published until 15 January 2017 and added data from the Italian ‘Biobanca Veneta per i Disturbi Alimentari’ biobank, performing a meta‐analysis comparing COMT Val158Met genotype and allele frequencies in EDs and anorexia nervosa (AN) or bulimia nervosa (BN) patients versus controls. Results Ten studies plus Biobanca Veneta per i Disturbi Alimentari (ED: n = 920, controls: n = 261 controls) with 3541 ED patients (AN = 2388; BN = 233) and 3684 controls were included. There were no significant group differences in COMT Val158Met alleles and genotype frequencies between patients and controls, for all EDs pooled together [range of odds ratios (ORs): 0.96–1.04, p‐values: 0.46–0.97, I2 = 0%] and when analysing separately patients with AN (ORs: 0.94–1.04, p‐values: 0.31–0.61, I2 = 0%) or BN (ORs: 0.80–1.09, p‐values: 0.28–0.64, I2 = 0–44%). Conclusions Meta‐analysing data results from 11 studies and 7225 subjects show that COMT Val158Met polymorphism is not associated with EDs. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.