Emergence of Toxin A-Negative, Toxin B-Positive Clostridium Difficile Strains: Epidemiological and Clinical Considerations

• Published in: Future microbiology Vol. 10; no. 1; pp. 1 - 4
• Main Authors: King, Amy M, Mackin, Kate E, Lyras, Dena
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.01.2015
• Subjects: Amino acids; Analysis; Animal populations; Animals; Antibiotics; Bacterial Proteins - genetics; Bacterial Toxins - genetics; Care and treatment; Clostridium difficile; Clostridium difficile - classification; Clostridium difficile - genetics; Clostridium difficile - pathogenicity; Clostridium Infections - epidemiology; Clostridium Infections - microbiology; Clostridium Infections - veterinary; Diagnosis; Enterotoxins - genetics; Epidemiology; Humans; Mortality; Ribotyping; Studies; Surveillance; North America; Europe; antibiotic-associated diarrhea; TcdA-B; ribotype 017; Clostridium difficile; toxin variants
• ISSN: 1746-0913; 1746-0921; 1746-0921
• DOI: 10.2217/fmb.14.115

[...]there has been a decrease in the prevalence of C. difficile disease, and specifically 027 strains, in North America and Europe [8], although other strain types, such as toxinotype V/ribotype 078, are now becoming more prevalent and more common in community-acquired infections [8,9]. Financial & competing interests disclosure The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript.