Ecofriendly microwave‐assisted reaction and extraction of bioactive compounds from hawthorn leaf
Introduction The main active components in hawthorn leaves possess various biological activities such as anti‐inflammatory, antioxidant, and hypolipidemic effects. Therefore, it is necessary to develop an effective and reliable extraction method to extract these active compounds from hawthorn leaves...
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| Published in | Phytochemical analysis Vol. 30; no. 6; pp. 710 - 719 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Wiley Subscription Services, Inc
01.11.2019
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| Online Access | Get full text |
| ISSN | 0958-0344 1099-1565 1099-1565 |
| DOI | 10.1002/pca.2849 |
Cover
| Abstract | Introduction
The main active components in hawthorn leaves possess various biological activities such as anti‐inflammatory, antioxidant, and hypolipidemic effects. Therefore, it is necessary to develop an effective and reliable extraction method to extract these active compounds from hawthorn leaves.
Objective
To establish a simple, rapid, and sensitive method for extraction and determination of polyphenolic compounds from hawthorn leaves.
Methods
In this study, a microwave‐assisted reaction and extraction (MARE) combined with ultra‐high‐performance liquid chromatography with ultraviolet detector method was established to extract and determine the polyphenolic compounds in hawthorn leaves. The solid reagent aqueous solutions were applied as extraction solvents, preventing the use of organic solvents. The target analytes were identified by quadrupole time‐of‐flight tandem mass spectrometry. Several experimental parameters that can significantly affect the extraction efficiency were evaluated and optimised.
Results
The optimal conditions were as follows: 0.1 g of sodium carbonate was used as solid reagent, the amount of sodium borate was set at 0.01 g, extraction time was 10 min, extraction temperature was set at 50°C, pH value was adjusted to 7. The validation experiments demonstrated that the method had high sensitivity with the limits of detection in the range 26.5–37.7 ng/mL. The average recoveries ranged from 80.22% to 93.27%.
Conclusion
In this work, the proposed MARE method was successfully applied to extract and determine polyphenolic compounds in hawthorn leaf samples. Compared with other reported methods, the present method was faster, greener, and more sensitive.
High extraction efficiencies and sensitivities of target compounds were achieved. The proposed method is a green, simple, easy operation, time‐saving and effective approach. |
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| AbstractList | Introduction
The main active components in hawthorn leaves possess various biological activities such as anti‐inflammatory, antioxidant, and hypolipidemic effects. Therefore, it is necessary to develop an effective and reliable extraction method to extract these active compounds from hawthorn leaves.
Objective
To establish a simple, rapid, and sensitive method for extraction and determination of polyphenolic compounds from hawthorn leaves.
Methods
In this study, a microwave‐assisted reaction and extraction (MARE) combined with ultra‐high‐performance liquid chromatography with ultraviolet detector method was established to extract and determine the polyphenolic compounds in hawthorn leaves. The solid reagent aqueous solutions were applied as extraction solvents, preventing the use of organic solvents. The target analytes were identified by quadrupole time‐of‐flight tandem mass spectrometry. Several experimental parameters that can significantly affect the extraction efficiency were evaluated and optimised.
Results
The optimal conditions were as follows: 0.1 g of sodium carbonate was used as solid reagent, the amount of sodium borate was set at 0.01 g, extraction time was 10 min, extraction temperature was set at 50°C, pH value was adjusted to 7. The validation experiments demonstrated that the method had high sensitivity with the limits of detection in the range 26.5–37.7 ng/mL. The average recoveries ranged from 80.22% to 93.27%.
Conclusion
In this work, the proposed MARE method was successfully applied to extract and determine polyphenolic compounds in hawthorn leaf samples. Compared with other reported methods, the present method was faster, greener, and more sensitive.
High extraction efficiencies and sensitivities of target compounds were achieved. The proposed method is a green, simple, easy operation, time‐saving and effective approach. INTRODUCTION: The main active components in hawthorn leaves possess various biological activities such as anti‐inflammatory, antioxidant, and hypolipidemic effects. Therefore, it is necessary to develop an effective and reliable extraction method to extract these active compounds from hawthorn leaves. OBJECTIVE: To establish a simple, rapid, and sensitive method for extraction and determination of polyphenolic compounds from hawthorn leaves. METHODS: In this study, a microwave‐assisted reaction and extraction (MARE) combined with ultra‐high‐performance liquid chromatography with ultraviolet detector method was established to extract and determine the polyphenolic compounds in hawthorn leaves. The solid reagent aqueous solutions were applied as extraction solvents, preventing the use of organic solvents. The target analytes were identified by quadrupole time‐of‐flight tandem mass spectrometry. Several experimental parameters that can significantly affect the extraction efficiency were evaluated and optimised. RESULTS: The optimal conditions were as follows: 0.1 g of sodium carbonate was used as solid reagent, the amount of sodium borate was set at 0.01 g, extraction time was 10 min, extraction temperature was set at 50°C, pH value was adjusted to 7. The validation experiments demonstrated that the method had high sensitivity with the limits of detection in the range 26.5–37.7 ng/mL. The average recoveries ranged from 80.22% to 93.27%. CONCLUSION: In this work, the proposed MARE method was successfully applied to extract and determine polyphenolic compounds in hawthorn leaf samples. Compared with other reported methods, the present method was faster, greener, and more sensitive. The main active components in hawthorn leaves possess various biological activities such as anti-inflammatory, antioxidant, and hypolipidemic effects. Therefore, it is necessary to develop an effective and reliable extraction method to extract these active compounds from hawthorn leaves.INTRODUCTIONThe main active components in hawthorn leaves possess various biological activities such as anti-inflammatory, antioxidant, and hypolipidemic effects. Therefore, it is necessary to develop an effective and reliable extraction method to extract these active compounds from hawthorn leaves.To establish a simple, rapid, and sensitive method for extraction and determination of polyphenolic compounds from hawthorn leaves.OBJECTIVETo establish a simple, rapid, and sensitive method for extraction and determination of polyphenolic compounds from hawthorn leaves.In this study, a microwave-assisted reaction and extraction (MARE) combined with ultra-high-performance liquid chromatography with ultraviolet detector method was established to extract and determine the polyphenolic compounds in hawthorn leaves. The solid reagent aqueous solutions were applied as extraction solvents, preventing the use of organic solvents. The target analytes were identified by quadrupole time-of-flight tandem mass spectrometry. Several experimental parameters that can significantly affect the extraction efficiency were evaluated and optimised.METHODSIn this study, a microwave-assisted reaction and extraction (MARE) combined with ultra-high-performance liquid chromatography with ultraviolet detector method was established to extract and determine the polyphenolic compounds in hawthorn leaves. The solid reagent aqueous solutions were applied as extraction solvents, preventing the use of organic solvents. The target analytes were identified by quadrupole time-of-flight tandem mass spectrometry. Several experimental parameters that can significantly affect the extraction efficiency were evaluated and optimised.The optimal conditions were as follows: 0.1 g of sodium carbonate was used as solid reagent, the amount of sodium borate was set at 0.01 g, extraction time was 10 min, extraction temperature was set at 50°C, pH value was adjusted to 7. The validation experiments demonstrated that the method had high sensitivity with the limits of detection in the range 26.5-37.7 ng/mL. The average recoveries ranged from 80.22% to 93.27%.RESULTSThe optimal conditions were as follows: 0.1 g of sodium carbonate was used as solid reagent, the amount of sodium borate was set at 0.01 g, extraction time was 10 min, extraction temperature was set at 50°C, pH value was adjusted to 7. The validation experiments demonstrated that the method had high sensitivity with the limits of detection in the range 26.5-37.7 ng/mL. The average recoveries ranged from 80.22% to 93.27%.In this work, the proposed MARE method was successfully applied to extract and determine polyphenolic compounds in hawthorn leaf samples. Compared with other reported methods, the present method was faster, greener, and more sensitive.CONCLUSIONIn this work, the proposed MARE method was successfully applied to extract and determine polyphenolic compounds in hawthorn leaf samples. Compared with other reported methods, the present method was faster, greener, and more sensitive. IntroductionThe main active components in hawthorn leaves possess various biological activities such as anti‐inflammatory, antioxidant, and hypolipidemic effects. Therefore, it is necessary to develop an effective and reliable extraction method to extract these active compounds from hawthorn leaves.ObjectiveTo establish a simple, rapid, and sensitive method for extraction and determination of polyphenolic compounds from hawthorn leaves.MethodsIn this study, a microwave‐assisted reaction and extraction (MARE) combined with ultra‐high‐performance liquid chromatography with ultraviolet detector method was established to extract and determine the polyphenolic compounds in hawthorn leaves. The solid reagent aqueous solutions were applied as extraction solvents, preventing the use of organic solvents. The target analytes were identified by quadrupole time‐of‐flight tandem mass spectrometry. Several experimental parameters that can significantly affect the extraction efficiency were evaluated and optimised.ResultsThe optimal conditions were as follows: 0.1 g of sodium carbonate was used as solid reagent, the amount of sodium borate was set at 0.01 g, extraction time was 10 min, extraction temperature was set at 50°C, pH value was adjusted to 7. The validation experiments demonstrated that the method had high sensitivity with the limits of detection in the range 26.5–37.7 ng/mL. The average recoveries ranged from 80.22% to 93.27%.ConclusionIn this work, the proposed MARE method was successfully applied to extract and determine polyphenolic compounds in hawthorn leaf samples. Compared with other reported methods, the present method was faster, greener, and more sensitive. High extraction efficiencies and sensitivities of target compounds were achieved. The proposed method is a green, simple, easy operation, time‐saving and effective approach. The main active components in hawthorn leaves possess various biological activities such as anti-inflammatory, antioxidant, and hypolipidemic effects. Therefore, it is necessary to develop an effective and reliable extraction method to extract these active compounds from hawthorn leaves. To establish a simple, rapid, and sensitive method for extraction and determination of polyphenolic compounds from hawthorn leaves. In this study, a microwave-assisted reaction and extraction (MARE) combined with ultra-high-performance liquid chromatography with ultraviolet detector method was established to extract and determine the polyphenolic compounds in hawthorn leaves. The solid reagent aqueous solutions were applied as extraction solvents, preventing the use of organic solvents. The target analytes were identified by quadrupole time-of-flight tandem mass spectrometry. Several experimental parameters that can significantly affect the extraction efficiency were evaluated and optimised. The optimal conditions were as follows: 0.1 g of sodium carbonate was used as solid reagent, the amount of sodium borate was set at 0.01 g, extraction time was 10 min, extraction temperature was set at 50°C, pH value was adjusted to 7. The validation experiments demonstrated that the method had high sensitivity with the limits of detection in the range 26.5-37.7 ng/mL. The average recoveries ranged from 80.22% to 93.27%. In this work, the proposed MARE method was successfully applied to extract and determine polyphenolic compounds in hawthorn leaf samples. Compared with other reported methods, the present method was faster, greener, and more sensitive. |
| Author | Peng, Li‐Qing Wang, Qiu‐Yan Liu, Fang‐Ming Yang, Juan Dong, Xin Wang, Shu‐Ling Cao, Jun Hu, Yu‐Han |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31264752$$D View this record in MEDLINE/PubMed |
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| Keywords | ultra-high-performance liquid chromatography microwave-assisted reaction and extraction quadrupole time-of-flight tandem mass spectrometry hawthorn leaf solid basic reagent polyphenolic compounds |
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| Snippet | Introduction
The main active components in hawthorn leaves possess various biological activities such as anti‐inflammatory, antioxidant, and hypolipidemic... High extraction efficiencies and sensitivities of target compounds were achieved. The proposed method is a green, simple, easy operation, time‐saving and... The main active components in hawthorn leaves possess various biological activities such as anti-inflammatory, antioxidant, and hypolipidemic effects.... IntroductionThe main active components in hawthorn leaves possess various biological activities such as anti‐inflammatory, antioxidant, and hypolipidemic... INTRODUCTION: The main active components in hawthorn leaves possess various biological activities such as anti‐inflammatory, antioxidant, and hypolipidemic... |
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| SubjectTerms | active ingredients Antioxidants Aqueous solutions Bioactive compounds chemical species Crataegus Crataegus - chemistry detection limit hawthorn leaf high performance liquid chromatography Hydrogen-Ion Concentration Inflammation Leaves Limit of Detection lipemic effect Liquid chromatography Mass spectrometry Mass spectroscopy microwave treatment Microwaves microwave‐assisted reaction and extraction Organic solvents phytochemicals Plant Leaves - chemistry polyphenolic compounds Polyphenols Polyphenols - analysis quadrupole time‐of‐flight tandem mass spectrometry Quadrupoles Reagents Reproducibility of Results Sodium Sodium borate Sodium borates Sodium carbonate solid basic reagent Solvents tandem mass spectrometry Target recognition temperature ultra-performance liquid chromatography Ultraviolet detectors ultra‐high‐performance liquid chromatography |
| Title | Ecofriendly microwave‐assisted reaction and extraction of bioactive compounds from hawthorn leaf |
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