The Addition of Low‐Dose Lidocaine and Triamcinolone Reduces the Adverse Effects of 2‐Deoxycholate Injection Without Affecting the Long‐Term Results

• Published in: Journal of cosmetic dermatology Vol. 24; no. 3; pp. e70072 - n/a
• Main Authors: Ge, Shealinna, Weiss, Robert A., Schilling, Laura, Noell, Claire M.
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.03.2025
• Subjects: Adult; Anesthetics, Local - administration & dosage; Anesthetics, Local - adverse effects; cosmetic dermatology; Cosmetic Techniques - adverse effects; Deoxycholic Acid - administration & dosage; Deoxycholic Acid - adverse effects; Double-Blind Method; Drug Therapy, Combination - methods; Edema - chemically induced; Edema - etiology; Edema - prevention & control; Female; Humans; Injections, Subcutaneous - adverse effects; intradermal injection; Lidocaine - administration & dosage; Lidocaine - adverse effects; local adiposity; Male; Middle Aged; Original; Subcutaneous Fat - drug effects; submental fat; Treatment Outcome; Triamcinolone Acetonide - administration & dosage; Triamcinolone Acetonide - adverse effects; submental fat; local adiposity; cosmetic dermatology; intradermal injection
• ISSN: 1473-2130; 1473-2165; 1473-2165
• DOI: 10.1111/jocd.70072

ABSTRACT Introduction The study investigates the efficacy of combining low‐dose triamcinolone acetonide (TAC) and lidocaine with deoxycholic acid (DCA) injections to reduce adverse effects (AEs) without compromising long‐term results. Methods A double‐blind, randomized trial was conducted with 15 subjects, divided into a control group (DCA with lidocaine) and an intervention group (DCA with low‐dose TAC and lidocaine). The primary outcomes measured were injection pain, swelling, and submental fat reduction. Results Results indicated that the intervention group experienced significantly reduced pain and swelling compared to the control group. Both groups showed similar efficacy in submental fat reduction, with the intervention group demonstrating a greater mean volumetric loss. Conclusion The study concludes that the addition of low‐dose TAC and lidocaine to DCA injections is a safe and effective method to enhance patient comfort and treatment outcomes without inducing steroid‐related side effects.