A New Pyridoxal Derivative for Transamination of N-Terminus of Proteins

A new pyridoxal-5-phosphate （PLP） derivative FHMDP was developed for the transamination of different pep- tides with three most hindered amino acid residues （Leu, Ile, Val） as their N-terminus. Compared to the previously reported reactions of PLP derivatives, the N-terminus transamination could be a...

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Bibliographic Details
Published inChinese journal of chemistry Vol. 29; no. 8; pp. 1715 - 1720
Main Author 张美娟 张学梅 李娟 郭庆祥
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.08.2011
WILEY‐VCH Verlag
Wiley
Wiley Subscription Services, Inc
Subjects
Amino acids
Bacteriology
Chemistry
Chemistry, Multidisciplinary
N-terminus
Peptides
Physical Sciences
PLP
PLP derivative
protein bioconjugation
protein modifications
Science & Technology
transamination
吡哆醛
异亮氨酸
新化合物
氨基酸残基
生物反应
蛋白质
衍生
N-terminus
protein modifications
transamination
protein bioconjugation
LIGATION
peptides
PLP derivative
STRATEGIES
Online AccessGet full text
ISSN1001-604X
1614-7065
DOI10.1002/cjoc.201180306

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Summary:A new pyridoxal-5-phosphate （PLP） derivative FHMDP was developed for the transamination of different pep- tides with three most hindered amino acid residues （Leu, Ile, Val） as their N-terminus. Compared to the previously reported reactions of PLP derivatives, the N-terminus transamination could be accomplished efficiently with the new compound.
Bibliography:A new pyridoxal-5-phosphate （PLP） derivative FHMDP was developed for the transamination of different pep- tides with three most hindered amino acid residues （Leu, Ile, Val） as their N-terminus. Compared to the previously reported reactions of PLP derivatives, the N-terminus transamination could be accomplished efficiently with the new compound.
31-1547/O6
transamination, N-terminus, protein bioconjugation, PLP derivative, peptides, protein modifications
istex:29AA2B890BD8C4C1E61CB49C82E5CE87D22D9E2D
ArticleID:CJOC201180306
the National Natural Science Foundation of China - No. 20932006 and 21002056
ark:/67375/WNG-QHQ9J9ZJ-Z
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201180306