Microwave-Assisted Aqueous Synthesis： A Rapid Approach to Poly-functionalized Indoline-Spiro Benzofurodiazepines

New cycloaddition has been established for the synthesis of indoline-spiro benzofurodiazepine derivatives. Those reactions were conducted by reacting readily available and inexpensive starting materials, such as ben- zene- 1,2-diamines, tetronic acid and indoline-2,3-diones, in aqueous solution unde...

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Bibliographic Details
Published in	Chinese journal of chemistry Vol. 29; no. 10; pp. 2101 - 2108
Main Author	王树良程闯龚峰吴飞跃姜波周建峰屠树江
Format	Journal Article
Language	English
Published	Weinheim WILEY-VCH Verlag 01.10.2011 WILEY‐VCH Verlag Wiley Wiley Subscription Services, Inc
Subjects	Aqueous solutions aqueous synthesis Benzene Chemistry Chemistry, Multidisciplinary Hydrocarbons indoline-spiro benzofurodiazepine Irradiation microwave chemistry multicomponent reactions Physical Sciences Science & Technology 区域选择性反应合成吲哚啉螺微波辅助微波辐射水溶液反应绿色合成苯二胺 multicomponent reactions ONE-POT SYNTHESIS aqueous synthesis ALKYLATION BOND FORMATIONS PHOSPHONYL IMINE CHEMISTRY indoline-spiro benzofurodiazepine TETRONIC ACIDS SPIROOXINDOLE DERIVATIVES microwave chemistry ADDITIONS MEDICINAL-PLANTS WATER
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ISSN	1001-604X 1614-7065
DOI	10.1002/cjoc.201180364

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Summary:	New cycloaddition has been established for the synthesis of indoline-spiro benzofurodiazepine derivatives. Those reactions were conducted by reacting readily available and inexpensive starting materials, such as ben- zene- 1,2-diamines, tetronic acid and indoline-2,3-diones, in aqueous solution under microwave irradiation. When mono-substituted benzene-l,2-diamines as an amine component was employed, the reaction regioselectively re- sulted in the poly-functionalized indoline-spiro benzofurodiazepine with good yields. The present green synthesis shows attractive characteristics such as the use of water as reaction media, concise one-pot conditions, short reaction periods, easy work-up/purification and reduced waste production without the use of any strong acids or metal promoters.
Bibliography:	Wang, Shuliang Cheng, Chuang Gong, Feng Wu, Feiyue Jiang, Bo Zhou, Jianfeng Tu, Shujiang（1. School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, Jiangsu 221116, China ;2. Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, Huaiyin Normal University, Huaian, Jiangsu 223300, China） indoline-spiro benzofurodiazepine, microwave chemistry, multicomponent reactions, aqueous synthe-sis 31-1547/O6 New cycloaddition has been established for the synthesis of indoline-spiro benzofurodiazepine derivatives. Those reactions were conducted by reacting readily available and inexpensive starting materials, such as ben- zene- 1,2-diamines, tetronic acid and indoline-2,3-diones, in aqueous solution under microwave irradiation. When mono-substituted benzene-l,2-diamines as an amine component was employed, the reaction regioselectively re- sulted in the poly-functionalized indoline-spiro benzofurodiazepine with good yields. The present green synthesis shows attractive characteristics such as the use of water as reaction media, concise one-pot conditions, short reaction periods, easy work-up/purification and reduced waste production without the use of any strong acids or metal promoters. the National Natural Science Foundation of China - No. 21072163 and 21002083 Science Foundation in Interdisciplinary Major Research Project of Xuzhou Normal University - No. 09XKXK01 Doctoral Research Foundation of Xuzhou Normal University - No. 10XLR20 istex:C95A2691D45FDFDC4DE485CB0492E261180EB433 Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials - No. JSKC07035 and JSKC09062 ArticleID:CJOC201180364 ark:/67375/WNG-QZ8QHK2N-M ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14
ISSN:	1001-604X 1614-7065
DOI:	10.1002/cjoc.201180364