Absorption, Distribution, Metabolism, and Excretion of Decursin and Decursinol Angelate from Angelica gigas Nakai

• Published in: Journal of microbiology and biotechnology Vol. 19; no. 12; pp. 1569 - 1572
• Main Authors: Kim, K.M., Inje University, Gimhae, Republic of Korea, Kim, M.J., Inje University, Gimhae, Republic of Korea, Kang, J.S., Kyungsung University, Busan, Republic of Korea
• Format: Journal Article
• Language: English
• Published: Seoul Korean Society for Applied Microbiology 01.12.2009; 한국미생물·생명공학회
• Subjects: Absorption; Administration, Oral; Angelica - chemistry; Angelica gigas Nakai; Animals; Benzopyrans - administration & dosage; Benzopyrans - chemistry; Benzopyrans - metabolism; Benzopyrans - pharmacokinetics; Biological and medical sciences; Biological Availability; Biotechnology; Butyrates - administration & dosage; Butyrates - chemistry; Butyrates - metabolism; Butyrates - pharmacokinetics; decursin; decursinol angelate; Enterohepatic Circulation; Feces - chemistry; Fundamental and applied biological sciences. Psychology; Injections, Intravenous; Intestine, Large - metabolism; Male; MEDICINAL PROPERTIES; Metabolic Clearance Rate; METABOLISM; METABOLISME; METABOLISMO; PROPIEDADES MEDICINALES; PROPRIETE PHARMACOLOGIQUE; Rats; Rats, Sprague-Dawley; Time Factors; Tissue Distribution; 생물학; Excretion; Absorption; decursinol angelate; Angelica gigas Nakai; Dicotyledones; Angiospermae; Angelica; decursin; Spermatophyta; Umbelliferae; Metabolism; Pharmacokinetics
• ISSN: 1017-7825; 1738-8872
• DOI: 10.4014/jmb.0905.05028

The pharmacokinetics of decursin and decursinol angelate (D/DA) were investigated in male SD rats following oral and intravenous administration. D/DA and metabolites obtained from in vitro samples were evaluated by LC/MS. The levels of D/DA and metabolized decursinol in the blood following oral and intravenous administrations declined according to first-order kinetics, with T∧1/2 values of 56.67, 58.01, and 57.22 h, respectively, being observed after administration of a dose of 2 mg/kg body weight. The large intestine was the major site of disposition following oral administration. These data indicate that D/DA is rapidly absorbed from the gastrointestinal tract. In in vitro experiment utilizing liver microsomal protein, the major metabolic reaction of D/DA occurred to change decursinol. The cumulative biliary, urinary, and fecal excretions of D/DA in bile duct-cannulated rats was 36.10±2.9%, 25.35±3.8%, and 34.20±3.2%, respectively, at 72 h after administration. These results indicate that the absorption of D/DA is almost complete, and that its metabolites are primarily excreted into feces through the bile. These results indicate that D/DA is subject to enterohepatic circulation.