Advanced thyroid carcinoma in pregnancy: case report of two pregnancies

• Published in: Gynecological endocrinology Vol. 31; no. 11; pp. 852 - 855
• Main Authors: Guerrero-Vázquez, Raquel, Moreno Reina, Eduardo, Gros Herguido, Noelia, Martínez Brocca, María Asunción, Navarro González, Elena
• Format: Journal Article
• Language: English
• Published: England 02.11.2015
• Subjects: Adenocarcinoma, Follicular - secondary; Adenocarcinoma, Follicular - therapy; Adult; Bone Density Conservation Agents - therapeutic use; Diphosphonates - therapeutic use; Female; Humans; Imidazoles - therapeutic use; Iodine Radioisotopes - therapeutic use; Lung Neoplasms - secondary; Lung Neoplasms - therapy; Lymph Node Excision; Metastasectomy; Pregnancy; Pregnancy Complications, Neoplastic - pathology; Pregnancy Complications, Neoplastic - therapy; Radiotherapy; Spinal Neoplasms - secondary; Spinal Neoplasms - therapy; Thyroid Neoplasms - pathology; Thyroid Neoplasms - therapy; Thyroidectomy; thyroid carcinoma; Fetal monitoring; prognosis; pregnancy
• ISSN: 0951-3590; 1473-0766
• DOI: 10.3109/09513590.2015.1018165

Differentiated thyroid carcinoma is one of the most frequently diagnosed cancers during pregnancy, second only to breast cancer. Therefore, it would be of value to determine if there are pregnancy-related physiological effects that impact long-term prognosis for patients with this disease. Hormone effects attributable to β-human chorionic gonadotropin and estrogens seem particularly likely. We present a case of a 40-year-old woman with thyroid follicular carcinoma with accompanying bone metastases. The cancer was discovered immediately after childbirth and the woman became pregnant again when the disease was in an advanced stage. We describe the cancer evolution and present the maternal and fetal results. Pregnancy in women with advanced thyroid carcinoma could affect long-term prognosis. However, more studies are needed to evaluate this hypothesis. In this unique case, there were two pregnancies and the second occurred in an advanced state of the disease. We evaluated how these pregnancies could affect short-term prognosis of the disease.