Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension

• Published in: Human molecular genetics Vol. 24; no. 3; pp. 865 - 874
• Main Authors: Lu, Xiangfeng, Wang, Laiyuan, Lin, Xu, Huang, Jianfeng, Charles Gu, C., He, Meian, Shen, Hongbing, He, Jiang, Zhu, Jingwen, Li, Huaixing, Hixson, James E., Wu, Tangchun, Dai, Juncheng, Lu, Ling, Shen, Chong, Chen, Shufeng, He, Lin, Mo, Zengnan, Hao, Yongchen, Mo, Xingbo, Yang, Xueli, Li, Jianxin, Cao, Jie, Chen, Jichun, Fan, Zhongjie, Li, Ying, Zhao, Liancheng, Li, Hongfan, Lu, Fanghong, Yao, Cailiang, Yu, Lin, Xu, Lihua, Mu, Jianjun, Wu, Xianping, Deng, Ying, Hu, Dongsheng, Zhang, Weidong, Ji, Xu, Guo, Dongshuang, Guo, Zhirong, Zhou, Zhengyuan, Yang, Zili, Wang, Renping, Yang, Jun, Zhou, Xiaoyang, Yan, Weili, Sun, Ningling, Gao, Pingjin, Gu, Dongfeng
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.02.2015
• Subjects: Adult; Aged; Asian People - genetics; Association Studies; Blood Pressure - genetics; Calcium Channels, L-Type - genetics; China; Female; Genetic Loci; Genetic Predisposition to Disease; Genome-Wide Association Study - methods; Humans; Hypertension - genetics; Male; Mediator Complex - genetics; Middle Aged; Polymorphism, Single Nucleotide; Sodium-Bicarbonate Symporters - genetics; Steroid 21-Hydroxylase - genetics; China
• ISSN: 0964-6906; 1460-2083; 1460-2083
• DOI: 10.1093/hmg/ddu478

Hypertension is a common disorder and the leading risk factor for cardiovascular disease and premature deaths worldwide. Genome-wide association studies (GWASs) in the European population have identified multiple chromosomal regions associated with blood pressure, and the identified loci altogether explain only a small fraction of the variance for blood pressure. The differences in environmental exposures and genetic background between Chinese and European populations might suggest potential different pathways of blood pressure regulation. To identify novel genetic variants affecting blood pressure variation, we conducted a meta-analysis of GWASs of blood pressure and hypertension in 11 816 subjects followed by replication studies including 69 146 additional individuals. We identified genome-wide significant (P < 5.0 × 10(-8)) associations with blood pressure, which included variants at three new loci (CACNA1D, CYP21A2, and MED13L) and a newly discovered variant near SLC4A7. We also replicated 14 previously reported loci, 8 (CASZ1, MOV10, FGF5, CYP17A1, SOX6, ATP2B1, ALDH2, and JAG1) at genome-wide significance, and 6 (FIGN, ULK4, GUCY1A3, HFE, TBX3-TBX5, and TBX3) at a suggestive level of P = 1.81 × 10(-3) to 5.16 × 10(-8). These findings provide new mechanistic insights into the regulation of blood pressure and potential targets for treatments.