Correlation Between Polarimetric Retinal Nerve Fiber Layer Thickness and Retinal Sensitivity Determined With Frequency-Doubling Technology

• Published in: Ophthalmic surgery, lasers & imaging Vol. 36; no. 5; pp. 394 - 400
• Main Authors: Katsanos, A, Kóthy, P, Konstas, A G P, Vargha, P, Holló, G
• Format: Journal Article
• Language: English
• Published: Thorofare, NJ SLACK Incorporated 01.09.2005; SLACK INCORPORATED
• Subjects: Adult; Anthropometry; Chronic Disease; Cross-Sectional Studies; Diagnostic Techniques, Ophthalmological; Glaucoma, Open-Angle - physiopathology; Humans; Lasers; Middle Aged; Nerve Fibers - pathology; Retina - physiology; Retinal Ganglion Cells - pathology
• ISSN: 1542-8877; 2325-8160; 2325-8179
• DOI: 10.3928/1542-8877-20050901-08

* BACKGROUND AND OBJECTIVE: Correlation between polarimetric retinal nerve fiber layer thickness measured with variable corneal compensation and retinal sensitivity measured with frequency-doubling technology (FDT) and standard automated perimetry (SAP) was investigated.* PATIENTS AND METHODS: Twenty-four consecutive patients with chronic open-angle glaucoma and 17 healthy control subjects (1 randomly selected eye for each subject) were evaluated.* RESULTS: For all subjects, quadrant scanning laser polarimetry parameters correlated positively with both FDT and SAP mean sensitivity of the opposite hemifield (P < .001). Global scanning laser polarimetry parameters correlated positively with FDT-mean sensitivity, SAP-mean sensitivity, and FDT-mean deviation, and negatively with SAP-mean deviation (in SAP, mean deviation is positive in case of sensitivity loss) (P ≤ .02). The nerve fiber indicator also correlated with FDT-pattern standard deviation and SAP-corrected loss variance (P ≤ .01). Using un-logged sensitivity values, no further correlations were found.* CONCLUSION: Our results show that a similar structure-function relationship exists between polarimetric retinal nerve fiber layer thickness determined with variable corneal compensation and retinal sensitivity measured with SAP and FDT.[Ophthalmic Surg Lasers Imaging 2005,36:394-400.]