Cough sensitivity to mannitol inhalation challenge identifies subjects with chronic cough

Cough is the most common reason why people seek medical attention [1]. Cough hypersensitivity syndrome (CHS) is a new concept to describe a condition with long-standing hypersensitivity of vagal afferent nerves or an alteration of the central processing of their input regardless of the underlying ca...

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Bibliographic Details
Published inThe European respiratory journal Vol. 51; no. 5; p. 1800294
Main Authors Koskela, Heikki O., Lake, Clair, Wong, Keith, Brannan, John D.
Format Journal Article
LanguageEnglish
Published England European Respiratory Society Journals Ltd 01.05.2018
Subjects
Cough
Hypersensitivity
Inhalation
Mannitol
Sensory neurons
Vagus nerve
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ISSN0903-1936
1399-3003
1399-3003
DOI10.1183/13993003.00294-2018

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Summary:Cough is the most common reason why people seek medical attention [1]. Cough hypersensitivity syndrome (CHS) is a new concept to describe a condition with long-standing hypersensitivity of vagal afferent nerves or an alteration of the central processing of their input regardless of the underlying cause [2]. The current definition of CHS is purely clinical; however, a test capable of demonstrating this hypersensitivity both reliably and feasibly might be used as a diagnostic test for CHS.
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ISSN:0903-1936
1399-3003
1399-3003
DOI:10.1183/13993003.00294-2018