Control of Intra-Thymic αβ T Cell Selection and Maturation by H3K27 Methylation and Demethylation

In addition to transcription factor binding, the dynamics of DNA modifications (methylation) and chromatin structure are essential contributors to the control of transcription in eukaryotes. Research in the past few years has emphasized the importance of histone H3 methylation at lysine 27 for linea...

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Published inFrontiers in immunology Vol. 10; p. 688
Main Author Bosselut, Rémy
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 2019
Subjects
H3K27 methylation
histone demethyalse
histone methylation
Immunology
polycomb
T cell development
thymus
H3K27 methylation
T cell development
histone demethyalse
histone methylation
thymus
polycomb
Online AccessGet full text
ISSN1664-3224
1664-3224
DOI10.3389/fimmu.2019.00688

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Summary:In addition to transcription factor binding, the dynamics of DNA modifications (methylation) and chromatin structure are essential contributors to the control of transcription in eukaryotes. Research in the past few years has emphasized the importance of histone H3 methylation at lysine 27 for lineage specific gene repression, demonstrated that deposition of this mark at specific genes is subject to differentiation-induced changes during development, and identified enzymatic activities, methyl transferases and demethylases, that control these changes. The present review discusses the importance of these mechanisms during intrathymic αβ T cell selection and late differentiation.
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Edited by: Keiko Ozato, National Institutes of Health (NIH), United States
Reviewed by: Yi Zhang, Temple University, United States; Maria L. Toribio, Severo Ochoa Molecular Biology Center (CSIC-UAM), Spain; Mahesh Bachu, Hospital for Special Surgery, United States
This article was submitted to T Cell Biology, a section of the journal Frontiers in Immunology
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2019.00688