Impact of cyclic bending on coronary hemodynamics

• Published in: Biomechanics and modeling in mechanobiology Vol. 22; no. 2; pp. 729 - 738
• Main Authors: Wang, Jiaqiu, Fang, Runxin, Wu, Hao, Xiang, Yuqiao, Mendieta, Jessica Benitez, Paritala, Phani Kumari, Fan, Zhenya, Anbananthan, Haveena, Amaya Catano, Jorge Alberto, Raffel, Owen Christopher, Li, Zhiyong
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2023; Springer Nature B.V
• Subjects: Bending; Biological and Medical Physics; Biomedical Engineering and Bioengineering; Biophysics; Computational fluid dynamics; Computer applications; Coronary artery; Coronary Vessels; Engineering; Flow velocity; Fluid dynamics; Heart - physiology; Heart rate; Hemodynamics; Humans; Hydrodynamics; Interaction models; Mathematical models; Models, Cardiovascular; Original Paper; Parameters; Shear stress; Stress, Mechanical; Theoretical and Applied Mechanics; Wall shear stresses; Coronary cyclic bending; Fluid–structure interaction; Hemodynamics
• ISSN: 1617-7959; 1617-7940; 1617-7940
• DOI: 10.1007/s10237-022-01677-z

It remains unknown that the degree of bias in computational fluid dynamics results without considering coronary cyclic bending. This study aims to investigate the influence of different rates of coronary cyclic bending on coronary hemodynamics. To model coronary bending, a multi-ring-controlled fluid–structural interaction model was designed. A coronary artery was simulated with various cyclic bending rates (0.5, 0.75 and 1 s, corresponding to heart rates of 120, 80 and 60 bpm) and compared against a stable model. The simulated results show that the hemodynamic parameters of vortex Q-criterion, temporal wall shear stress (WSS), time-averaged WSS (TaWSS) and oscillatory shear index (OSI) were sensitive to the changes in cyclic rate. A higher heart rate resulted in higher magnitude and larger variance in the hemodynamic parameters. Whereas, the values and distributions of flow velocity and relative residence time (RRT) did not show significant differences between different bending periods. This study suggests that a stable coronary model is not sufficient to represent the hemodynamics in a bending coronary artery. Different heart rate conditions were found to have significant impact on the hemodynamic parameters. Thus, cyclic bending should be considered to mimic the realistic hemodynamics in future patient-specific coronary hemodynamics studies.