Distal hereditary motor neuronopathy as a new phenotype associated with variants in BAG3

• Published in: Journal of neurology Vol. 271; no. 2; pp. 986 - 994
• Main Authors: de Fuenmayor-Fernández de la Hoz, Carlos Pablo, Lupo, Vincenzo, Bermejo-Guerrero, Laura, Martín-Jiménez, Paloma, Hernández-Laín, Aurelio, Olivé, Montse, Gallardo, Eduard, Esteban-Pérez, Jesús, Espinós, Carmen, Domínguez-González, Cristina
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2024; Springer Nature B.V
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adult; Aged; Apoptosis Regulatory Proteins - genetics; Atrophy; Biopsy; Cardiomyopathy; Charcot-Marie-Tooth disease; Charcot-Marie-Tooth Disease - genetics; Differential diagnosis; Dilated cardiomyopathy; Female; Genotype & phenotype; Humans; Medicine; Medicine & Public Health; Middle Aged; Muscle, Skeletal - diagnostic imaging; Muscle, Skeletal - pathology; Muscular Atrophy, Spinal - pathology; Mutation - genetics; Myopathy; Neurology; Neuropathy; Neuroradiology; Neurosciences; Original Communication; Pedigree; Phenotype; Phenotypes; Reflexes; Skeletal muscle; BAG3; Distal hereditary motor neuronopathies; Neuromuscular diseases
• ISSN: 0340-5354; 1432-1459; 1432-1459
• DOI: 10.1007/s00415-023-12039-9

Objective To describe a new phenotype associated with a novel variant in BAG3 : autosomal dominant adult-onset distal hereditary motor neuronopathy. Methods This study enrolled eight affected individuals from a single family and included a comprehensive evaluation of the clinical phenotype, neurophysiologic testing, muscle MRI, muscle biopsy and western blot of BAG3 protein in skeletal muscle. Genetic workup included whole exome sequencing and segregation analysis of the detected variant in BAG3 . Results Seven patients developed slowly progressive and symmetric distal weakness and atrophy of lower limb muscles, along with absent Achilles reflexes. The mean age of onset was 46 years. The neurophysiological examination was consistent with the diagnosis of distal motor neuronopathy. One 57-year-old female patient was minimally symptomatic. The pattern of inheritance was autosomal dominant, with one caveat: one female patient who was an obligate carrier of the variant died at the age of 73 years without exhibiting any muscle weakness. The muscle biopsies revealed neurogenic changes. A novel heterozygous truncating variant c.1513_1514insGGAC (p.Val505GlyfsTer6) in the gene BAG3 was identified in all affected family members. Conclusions We report an autosomal dominant adult-onset distal hereditary motor neuronopathy with incomplete penetrance in women as a new phenotype related to a truncating variant in the BAG3 gene. Our findings expand the phenotypic spectrum of BAG3 -related disorders, which previously included dilated cardiomyopathy, myofibrillar myopathy and adult-onset Charcot-Marie-Tooth type 2 neuropathy. Variants in BAG3 should be considered in the differential diagnosis of distal hereditary motor neuronopathies.