Role of a portable gamma-camera with optical view for margins assessment of pulmonary nodules resected by radioguided surgery

• Published in: European journal of nuclear medicine and molecular imaging Vol. 49; no. 1; pp. 361 - 370
• Main Authors: Vollmer, Ivan, Sánchez-Izquierdo, Nuria, Martínez, Daniel, Sánchez-Lorente, David, Casanueva-Eliceiry, Sebastián, Boada, Marc, Guirao, Ángela, Romero-Zayas, Inmaculada, Vidal-Sicart, Sergi, Paredes, Pilar
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2021; Springer Nature B.V
• Subjects: Cameras; Cardiology; Gamma Cameras; Humans; Imaging; Lesions; Localization; Lung Neoplasms - diagnostic imaging; Lung Neoplasms - surgery; Lung nodules; Medical imaging; Medicine; Medicine & Public Health; Multiple Pulmonary Nodules; Nodules; Nuclear Medicine; Oncology; Oncology – Chest; Original Article; Orthopedics; Portability; Radioactive tracers; Radiology; Radionuclide Imaging; Surgery, Computer-Assisted; Radioguided surgery; Portable gamma-camera; Pulmonary nodules; Margin assessment
• ISSN: 1619-7070; 1619-7089; 1619-7089
• DOI: 10.1007/s00259-021-05466-1

Purpose Radioguided occult lesion localization (ROLL) of pulmonary nodules is an alternative to hook-wire. Both required of a histological margin assessment. The activity emerging from the radiotracer allows to obtain an intraoperative scintigraphic image of the surgical specimen by a portable gamma-camera (PGC) fitted with an optical view, which provides information about the localization of the nodule in relation to the margins. The aim of this study was to evaluate the intraoperative use of a PGC for margin assessment of pulmonary nodules. Methods ROLL technique was used in 38 nodules (36 pulmonary, 1 chest wall, and 1 pleural nodules). A PGC intraoperative image of the surgical specimen was obtained in 32. Scintigraphic results were compared to the histological assessment. Other factors, such as nodule size, distance from the pleural surface, or distance covered by the needle, were considered as possible factors for non-centered lesions. Results PGC images showed that the lesion was in contact with the margins in 8/32 cases and centered in 24. In all cases in which the lesion was considered as centered by the PGC, the margins were free of involvement (NPV 100%), although the PPV is low. Conclusions The use of a PGC for margin assessment after pulmonary nodule resection is feasible and provides a high NPV in our series. In addition, the short intraoperative time required for its use makes the PGC a useful tool for providing supplementary information to histopathologic results. Further studies from different surgical teams are required for an external validation.