Trajectory of Preserved Ratio Impaired Spirometry: Natural History and Long-Term Prognosis

• Published in: American journal of respiratory and critical care medicine Vol. 204; no. 8; pp. 910 - 920
• Main Authors: Marott, Jacob Louis, Ingebrigtsen, Truls Sylvan, Çolak, Yunus, Vestbo, Jørgen, Lange, Peter
• Format: Journal Article
• Language: English
• Published: New York American Thoracic Society 15.10.2021
• Subjects: Cardiovascular disease; Medical prognosis; Mortality; Spirometry
• ISSN: 1073-449X; 1535-4970; 1535-4970
• DOI: 10.1164/rccm.202102-0517OC

Marott et al discuss their study on the natural history and long-term prognosis of the following PRISm trajectories: persistent PRISm trajectory (individuals with PRISm both young and middle-aged), normal to PRISm trajectory (individuals developing PRISm from normal spirometry in young adulthood), and PRISm to normal trajectory (individuals recovering from PRISm in young adulthood by normalizing spirometry while middle-aged). They followed 1,160 individuals from the Copenhagen City Heart Study from 1976 to 1983 until 2001 to 2003 to determine their lung function trajectory. From 2001-2003 until 2018, they determined the risk of cardiopulmonary disease and death. They found that PRISm in middle-aged individuals is associated with increased risk of cardiopulmonary disease and all-cause mortality, but individuals who recover from PRISm during their adult life are no longer at increased risk.