Biocompatible Material‐Based Flexible Biosensors: From Materials Design to Wearable/Implantable Devices and Integrated Sensing Systems

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 19; no. 27; pp. e2207879 - n/a
• Main Authors: Liu, Gang, Lv, Ziyu, Batool, Saima, Li, Ming‐Zheng, Zhao, Pengfei, Guo, Liangchao, Wang, Yan, Zhou, Ye, Han, Su‐Ting
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.07.2023
• Subjects: Artificial intelligence; Biocompatibility; biocompatible materials; Biomedical materials; Biosensors; Chemical sensors; flexible biosensors; Inorganic materials; Internet of Things; in‐sensor computing; Nanotechnology; Organic materials; Temperature sensors; transistors; Wearable technology; wearable/implantable devices; flexible biosensors; biocompatible materials; wearable/implantable devices; in-sensor computing; transistors
• ISSN: 1613-6810; 1613-6829; 1613-6829
• DOI: 10.1002/smll.202207879

Human beings have a greater need to pursue life and manage personal or family health in the context of the rapid growth of artificial intelligence, big data, the Internet of Things, and 5G/6G technologies. The application of micro biosensing devices is crucial in connecting technology and personalized medicine. Here, the progress and current status from biocompatible inorganic materials to organic materials and composites are reviewed and the material‐to‐device processing is described. Next, the operating principles of pressure, chemical, optical, and temperature sensors are dissected and the application of these flexible biosensors in wearable/implantable devices is discussed. Different biosensing systems acting in vivo and in vitro, including signal communication and energy supply are then illustrated. The potential of in‐sensor computing for applications in sensing systems is also discussed. Finally, some essential needs for commercial translation are highlighted and future opportunities for flexible biosensors are considered. Flexible biosensors (pressure, optical, temperature, and electrochemical sensors) prepared from various biocompatible materials have the capability to monitor physiological signals such as heart rate, temperature, and body fluid markers. Sophisticated wearable/implantable sensors and systems for optimizing every aspect of the personal health and performance can be achieved through rational design of functional material and device architecture, as well as the use of advanced processing/integration approaches.