Diterpenoids from Euphorbia neriifolia and Their Related Anti‐HIV and Cytotoxic Activity
Fifteen diterpenoids (1–15), including three undescribed ones with ent‐atisane skeleton, eupnerias G–I (1–3), were obtained from Euphorbia neriifolia. Compounds 1–3 were established through comprehensive spectroscopic analysis. Compounds 4 and 5 exhibited obvious anti‐HIV‐1 effect, and their EC50 we...
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| Published in | Chemistry & biodiversity Vol. 16; no. 12; pp. e1900495 - n/a |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Wiley Subscription Services, Inc
01.12.2019
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| Online Access | Get full text |
| ISSN | 1612-1872 1612-1880 1612-1880 |
| DOI | 10.1002/cbdv.201900495 |
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| Abstract | Fifteen diterpenoids (1–15), including three undescribed ones with ent‐atisane skeleton, eupnerias G–I (1–3), were obtained from Euphorbia neriifolia. Compounds 1–3 were established through comprehensive spectroscopic analysis. Compounds 4 and 5 exhibited obvious anti‐HIV‐1 effect, and their EC50 were 6.6±3.2 and 6.4±2.5 μg mL−1, respectively. Compound 6 exhibited moderate cytotoxicity on HepG2 and HepG2/Adr cells with IC50 at 13.70 and 15.57 μm, respectively. In addition, compound 15 exhibited significant cytotoxicity on HepG2 cell lines (IC50=0.01 μm), while it did not show any cytotoxicity against HepG2/Adr cell lines. |
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| AbstractList | Fifteen diterpenoids (1–15), including three undescribed ones with ent‐atisane skeleton, eupnerias G–I (1–3), were obtained from Euphorbia neriifolia. Compounds 1–3 were established through comprehensive spectroscopic analysis. Compounds 4 and 5 exhibited obvious anti‐HIV‐1 effect, and their EC50 were 6.6±3.2 and 6.4±2.5 μg mL−1, respectively. Compound 6 exhibited moderate cytotoxicity on HepG2 and HepG2/Adr cells with IC50 at 13.70 and 15.57 μm, respectively. In addition, compound 15 exhibited significant cytotoxicity on HepG2 cell lines (IC50=0.01 μm), while it did not show any cytotoxicity against HepG2/Adr cell lines. Fifteen diterpenoids ( 1 – 15 ), including three undescribed ones with ent ‐atisane skeleton, eupnerias G–I ( 1 – 3 ), were obtained from Euphorbia neriifolia . Compounds 1 – 3 were established through comprehensive spectroscopic analysis. Compounds 4 and 5 exhibited obvious anti‐HIV‐1 effect, and their EC 50 were 6.6±3.2 and 6.4±2.5 μg mL −1 , respectively. Compound 6 exhibited moderate cytotoxicity on HepG2 and HepG2/Adr cells with IC 50 at 13.70 and 15.57 μ m , respectively. In addition, compound 15 exhibited significant cytotoxicity on HepG2 cell lines (IC 50 =0.01 μ m ), while it did not show any cytotoxicity against HepG2/Adr cell lines. Fifteen diterpenoids (1-15), including three undescribed ones with ent-atisane skeleton, eupnerias G-I (1-3), were obtained from Euphorbia neriifolia. Compounds 1-3 were established through comprehensive spectroscopic analysis. Compounds 4 and 5 exhibited obvious anti-HIV-1 effect, and their EC were 6.6±3.2 and 6.4±2.5 μg mL , respectively. Compound 6 exhibited moderate cytotoxicity on HepG2 and HepG2/Adr cells with IC at 13.70 and 15.57 μm, respectively. In addition, compound 15 exhibited significant cytotoxicity on HepG2 cell lines (IC =0.01 μm), while it did not show any cytotoxicity against HepG2/Adr cell lines. Fifteen diterpenoids (1-15), including three undescribed ones with ent-atisane skeleton, eupnerias G-I (1-3), were obtained from Euphorbia neriifolia. Compounds 1-3 were established through comprehensive spectroscopic analysis. Compounds 4 and 5 exhibited obvious anti-HIV-1 effect, and their EC50 were 6.6±3.2 and 6.4±2.5 μg mL-1 , respectively. Compound 6 exhibited moderate cytotoxicity on HepG2 and HepG2/Adr cells with IC50 at 13.70 and 15.57 μm, respectively. In addition, compound 15 exhibited significant cytotoxicity on HepG2 cell lines (IC50 =0.01 μm), while it did not show any cytotoxicity against HepG2/Adr cell lines.Fifteen diterpenoids (1-15), including three undescribed ones with ent-atisane skeleton, eupnerias G-I (1-3), were obtained from Euphorbia neriifolia. Compounds 1-3 were established through comprehensive spectroscopic analysis. Compounds 4 and 5 exhibited obvious anti-HIV-1 effect, and their EC50 were 6.6±3.2 and 6.4±2.5 μg mL-1 , respectively. Compound 6 exhibited moderate cytotoxicity on HepG2 and HepG2/Adr cells with IC50 at 13.70 and 15.57 μm, respectively. In addition, compound 15 exhibited significant cytotoxicity on HepG2 cell lines (IC50 =0.01 μm), while it did not show any cytotoxicity against HepG2/Adr cell lines. |
| Author | Feng, Xiao‐Yi Chen, Xuan‐Qin Li, Hong‐Mei Li, Jian‐Chun Li, Rong‐Tao Liu, Dan Zhang, Zhi‐Jun |
| Author_xml | – sequence: 1 givenname: Jian‐Chun orcidid: 0000-0001-9689-2127 surname: Li fullname: Li, Jian‐Chun organization: Kunming University of Science and Technology – sequence: 2 givenname: Xiao‐Yi surname: Feng fullname: Feng, Xiao‐Yi organization: Kunming University of Science and Technology – sequence: 3 givenname: Dan surname: Liu fullname: Liu, Dan organization: Kunming University of Science and Technology – sequence: 4 givenname: Zhi‐Jun surname: Zhang fullname: Zhang, Zhi‐Jun organization: Kunming University of Science and Technology – sequence: 5 givenname: Xuan‐Qin surname: Chen fullname: Chen, Xuan‐Qin organization: Kunming University of Science and Technology – sequence: 6 givenname: Rong‐Tao surname: Li fullname: Li, Rong‐Tao organization: Kunming University of Science and Technology – sequence: 7 givenname: Hong‐Mei surname: Li fullname: Li, Hong‐Mei email: lihongmei0823@163.com organization: Kunming University of Science and Technology |
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| Cites_doi | 10.1016/S0040-4020(01)86461-9 10.1016/j.ejmech.2018.07.020 10.3736/jcim20121115 10.1021/acsmedchemlett.5b00339 10.1021/np5004752 10.1021/acs.jnatprod.8b00493 10.1021/cr400541j 10.1016/j.phymed.2012.11.005 10.1016/j.apjtm.2017.05.003 10.1002/cbdv.201700560 10.1016/j.phytochem.2011.11.016 10.1016/0031-9422(88)80232-2 10.1016/0031-9422(90)85140-B 10.1021/acs.jnatprod.8b00600 10.1016/j.phytochem.2017.10.006 10.1016/0031-9422(90)85042-E 10.1107/S0108270191011319 |
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| Keywords | anti-HIV, cytotoxic activity Euphorbia neriifolia ent-atisane diterpenoids |
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| SubjectTerms | Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology anti-HIV, cytotoxic activity Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Biotechnology Cell Line, Tumor Cell lines Cell Survival - drug effects Cytotoxicity Diterpenes Diterpenes - chemistry Diterpenes - pharmacology Drug Resistance, Neoplasm - drug effects ent-atisane diterpenoids Euphorbia - chemistry Euphorbia - metabolism Euphorbia neriifolia HIV HIV-1 - drug effects Human immunodeficiency virus Humans Molecular Conformation Structure-Activity Relationship Toxicity |
| Title | Diterpenoids from Euphorbia neriifolia and Their Related Anti‐HIV and Cytotoxic Activity |
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