Diterpenoids from Euphorbia neriifolia and Their Related Anti‐HIV and Cytotoxic Activity

• Published in: Chemistry & biodiversity Vol. 16; no. 12; pp. e1900495 - n/a
• Main Authors: Li, Jian‐Chun, Feng, Xiao‐Yi, Liu, Dan, Zhang, Zhi‐Jun, Chen, Xuan‐Qin, Li, Rong‐Tao, Li, Hong‐Mei
• Format: Journal Article
• Language: English
• Published: Switzerland Wiley Subscription Services, Inc 01.12.2019
• Subjects: Anti-HIV Agents - chemistry; Anti-HIV Agents - pharmacology; anti-HIV, cytotoxic activity; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; Biotechnology; Cell Line, Tumor; Cell lines; Cell Survival - drug effects; Cytotoxicity; Diterpenes; Diterpenes - chemistry; Diterpenes - pharmacology; Drug Resistance, Neoplasm - drug effects; ent-atisane diterpenoids; Euphorbia - chemistry; Euphorbia - metabolism; Euphorbia neriifolia; HIV; HIV-1 - drug effects; Human immunodeficiency virus; Humans; Molecular Conformation; Structure-Activity Relationship; Toxicity; anti-HIV, cytotoxic activity; Euphorbia neriifolia; ent-atisane diterpenoids
• ISSN: 1612-1872; 1612-1880; 1612-1880
• DOI: 10.1002/cbdv.201900495

Fifteen diterpenoids (1–15), including three undescribed ones with ent‐atisane skeleton, eupnerias G–I (1–3), were obtained from Euphorbia neriifolia. Compounds 1–3 were established through comprehensive spectroscopic analysis. Compounds 4 and 5 exhibited obvious anti‐HIV‐1 effect, and their EC50 were 6.6±3.2 and 6.4±2.5 μg mL−1, respectively. Compound 6 exhibited moderate cytotoxicity on HepG2 and HepG2/Adr cells with IC50 at 13.70 and 15.57 μm, respectively. In addition, compound 15 exhibited significant cytotoxicity on HepG2 cell lines (IC50=0.01 μm), while it did not show any cytotoxicity against HepG2/Adr cell lines.