The Significant Association of MMP-1 Genotypes With Taiwan Pterygium

• Published in: Anticancer research Vol. 40; no. 2; pp. 703 - 707
• Main Authors: TSAI, CHONG-BIN, HSIA, NING-YI, WANG, YUN-CHI, WANG, ZHI-HONG, CHIN, YU-TING, HUANG, TAI-LIN, YU, CHIEN-CHIH, CHANG, WEN-SHIN, TSAI, CHIA-WEN, YIN, MEI-CHIN, BAU, DA-TIAN
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.02.2020
• Subjects: Age; Aged; Aged, 80 and over; Alleles; Angiogenesis; Apoptosis; Cancer; Extracellular matrix; Female; Fibroblasts; Gender; Gene polymorphism; Genotype; Genotype & phenotype; Genotypes; Humans; Interstitial collagenase; Investigations; Male; Matrix metalloproteinase; Matrix Metalloproteinase 1 - genetics; Matrix metalloproteinases; Middle Aged; Polymerase chain reaction; Polymorphism; Pterygium - enzymology; Pterygium - epidemiology; Pterygium - genetics; Restriction fragment length polymorphism; Taiwan - epidemiology; Taiwan; pterygium; gender; MMP-1; Taiwan; polymorphism; Age; genotype
• ISSN: 0250-7005; 1791-7530; 1791-7530
• DOI: 10.21873/anticanres.14000

Few studies have examined the contribution of matrix metalloproteinases (MMP) to either diagnosis or prognosis of pterygium. The aim of this study was to investigate the contribution of MMP-1 genotypes to pterygium risk. A total of 134 cases and 268 controls were included and their MMP-1 -1607 (rs1799705) genotypes were examined by polymerase chain reaction-restriction fragment length polymorphism. The percentages of 2G/2G, 1G/2G, and 1G/1G for rs1799705 genotypes were 48.5, 36.6 and 14.9% among patients and 33.9, 44.8, and 21.3% among controls (p trend=0.0167). The odds ratios (ORs) after adjusting for age and gender for 1G/2G and 1G/1G genotypes at rs1799705 were 0.54 (95%CI=0.33-0.89, p=0.0168) and 0.46 (95%CI=0.27-0.88, p=0.0192), respectively. Consistently, the adjusted OR for those carrying the 1G allele at MMP-1 -1607 was 0.61 (95%CI=0.41-0.78, p=0.0167), compared with the wild-type 2G allele. The genotypes at rs1799705 play a role in determining personal susceptibility to pterygium.