Characteristics of children with sporadic hemolytic uremic syndrome in a single Northern California center

• Published in: International urology and nephrology Vol. 44; no. 5; pp. 1467 - 1472
• Main Authors: Oh, Gia, Lau, Keith K.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.10.2012; Springer Nature B.V
• Subjects: Adolescent; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Anuria - etiology; Blood Pressure; Blood Urea Nitrogen; California; Chi-Square Distribution; Child; Child, Preschool; Creatinine - blood; Creatinine - urine; Dialysis; Diarrhea - etiology; Escherichia coli - isolation & purification; Female; Follow-Up Studies; Gastrointestinal Hemorrhage - etiology; Glomerular Filtration Rate; Hemolytic-Uremic Syndrome - complications; Hemolytic-Uremic Syndrome - microbiology; Hemolytic-Uremic Syndrome - physiopathology; Hemolytic-Uremic Syndrome - therapy; Humans; Infant; Length of Stay; Male; Medicine; Medicine & Public Health; Nephrology; Nephrology - Original Paper; Proteinuria - drug therapy; Proteinuria - etiology; Rectal Diseases - etiology; Retrospective Studies; Statistics, Nonparametric; Urology; California; Children; California; Hemolytic uremic syndrome; Outcomes
• ISSN: 0301-1623; 1573-2584; 1573-2584
• DOI: 10.1007/s11255-011-0083-y

Purpose Hemolytic uremic syndrome (HUS) is a frequent cause of acute kidney injury in children. The aim of this study is to describe our experience at a Northern California center. Methods Medical records of children suffered from HUS (08/99 to 03/09) at University of California Davis Medical Center were reviewed. Results Forty-six children (70% girls) were studied, and their median age was 3.5 years. Diarrhea was a presenting symptom in 42 subjects (91%), and hematochezia was present in 31 children (67%). Escherichia coli 0157:H7 was isolated in 20 patients (44%). Thirteen subjects (28%) underwent dialysis for a median of 7 days during their hospitalization. Follow-up was achieved in 36 patients (78.3%) for a median of 16 months. One patient required angiotensin-converting enzyme (ACE) inhibitor for proteinuria but none was on dialysis. Conclusions In our cohort in children with HUS in a single Californian center, long-term complications were uncommon during a median follow-up time of 16 months.