A bioinformatics view of zinc enzymes

• Published in: Journal of inorganic biochemistry Vol. 111; pp. 150 - 156
• Main Authors: Andreini, Claudia, Bertini, Ivano
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2012
• Subjects: Animals; Bioinformatics; Computational Biology - methods; Databases, Protein; Humans; Metalloproteins - chemistry; Metalloproteins - metabolism; Proteomics - methods; Zinc; Zinc - chemistry; Zinc - metabolism; Zinc enzymes; Zinc proteins; Zinc proteins; Zinc enzymes; Databases; Bioinformatics; Zinc
• ISSN: 0162-0134; 1873-3344; 1873-3344
• DOI: 10.1016/j.jinorgbio.2011.11.020

Thanks to the contributions of scientists like Bert Vallee, zinc enzymology is an area of research with a rich history and a strong basis of biochemical and biophysical knowledge. In recent years, the dramatic development of the genomic and post-genomic research has provided this as well as all other fields of life sciences with a massive body of new data, including, but not limited to, protein sequence and structural data. By integrating these new data with the wealth of information available in the literature, it is possible to achieve an unprecedented overview of the properties and functions of zinc enzymes in the context of biological systems. To this aim, the role of bioinformatics is essential. In this work, we use bioinformatics tools and databases that we have developed for the study of metalloproteins to gain insights into the functions of zinc in zinc enzymes, its coordination properties, and the usage of zinc enzymes in living organisms. Bioinformatics tools and databases that we have developed in recent years are used to achieve a bird's eye view on the major subject matter of Bert Vallee's research, i.e., zinc enzymes. [Display omitted] ► Zinc enzymology has a strong basis of biochemical and biophysical knowledge. ► Many protein sequence and structural data are now available for zinc enzymes. ► Bioinformatics can offer an unprecedented overview of zinc enzymes. ► Bioinformatics is used to analyze the properties and roles of zinc in enzymes. ► Bioinformatics is used to analyze the usage of zinc enzymes in organisms.