Synthetic routes to nanomaterials containing anthracyclines: noncovalent systems
Chemotherapy still constitutes a basic treatment for various types of cancer. Anthracyclines are effective antineoplastic drugs that are widely used in clinical practice. Unfortunately, they are characterized by high systemic toxicity and lack of tumour selectivity. A promising way to enhance treatm...
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| Published in | Biomaterials science Vol. 6; no. 1; pp. 2552 - 2565 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
25.09.2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 2047-4830 2047-4849 2047-4849 |
| DOI | 10.1039/c8bm00739j |
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| Summary: | Chemotherapy still constitutes a basic treatment for various types of cancer. Anthracyclines are effective antineoplastic drugs that are widely used in clinical practice. Unfortunately, they are characterized by high systemic toxicity and lack of tumour selectivity. A promising way to enhance treatment effectiveness and reduce toxicity is the synthesis of systems containing anthracyclines either in the form of complexes for the encapsulation of active drugs or their covalent conjugates with inert carriers. In this respect nanotechnology offers an extensive spectrum of possible solutions. In this review, we discuss recent advances in the development of anthracycline prodrugs based on nanocarriers such as copolymers, lipids, DNA, and inorganic systems. The review focuses on the chemical architecture of the noncovalent nanocarrier-drug systems.
Anthracyclines are very effective antibiotics widely used in chemotherapy; however, they also exert serious side effects. An important pathway to limit their general toxicity is encapsulation within nanocarriers, as exemplified in the graphics. It is a hot research subject with over 80 papers in the last 5 years. |
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| Bibliography: | Kinga Piorecka is currently pursuing her PhD degree on silsesquioxane nanocarriers for anthracyclines at the Centre of Molecular and Macromolecular Studies of the Polish Academy of Sciences in Lodz. She graduated from the Department of Inorganic Chemistry, University of Lodz. Her research interests include organometallic synthesis and biomaterials. Dr Jan Kurjata is a Research Fellow at the Centre of Molecular and Macromolecular Studies of the Polish Academy of Sciences (CMMS) in Lodz. He graduated from the Department of Chemistry, Lodz University of Technology and obtained his PhD from CMMS. He undertook a one year sabbatical stay at the Tokyo University of Agriculture and Technology. His current research focuses on organosilicon polymers, silicon quantum dots and nanotechnology. Prof. Wlodzimierz Stanczyk is a leader of the Inorganic-Organic Composites Research Group at the Centre of Molecular and Macromolecular Studies of the Polish Academy of Sciences in Lodz. He obtained his MSc Eng., PhD and DSc from the Chemistry Department of the Lodz University of Technology. He spent over two years working with Prof. Colin Eaborn at the School of Molecular Sciences of the University of Sussex. He has published over 100 papers on various aspects of organosilicon polymers and organometallic reaction mechanisms, liquid crystal polymers and nanoconjugates. His current interests focus on silsesquioxanes and quantum dots as drug nanocarriers. Dr Maciej Stanczyk is an active oncologic surgeon. He graduated and received his PhD degree from the Medical University of Lodz. Apart from his professional activities his research interests include chemotherapy and application of dendrimers as drug nanocarriers. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ISSN: | 2047-4830 2047-4849 2047-4849 |
| DOI: | 10.1039/c8bm00739j |