Acute Basilar Artery Occlusion in the Basilar Artery International Cooperation Study Does Gender Matter?

• Published in: Stroke (1970) Vol. 41; no. 11; pp. 2693 - 2696
• Main Authors: Arnold, Marcel, Fischer, Urs, Compter, Annette, Gralla, Jan, Findling, Oliver, Mattle, Heinrich P., Kappelle, L. Jaap, Tanne, David, Algra, Ale, Schonewille, Wouter J.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.11.2010
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Cardiovascular system; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges; Female; Fibrinolytic Agents - administration & dosage; Fibrinolytic Agents - therapeutic use; Fundamental and applied biological sciences. Psychology; Humans; Injections, Intra-Arterial; Injections, Intravenous; Male; Medical sciences; Middle Aged; Neurology; Neurosurgery; Pharmacology. Drug treatments; Registries; Sex Characteristics; Skull, brain, vascular surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Survival Rate; Thrombolytic Therapy; Treatment Outcome; Vascular diseases and vascular malformations of the nervous system; Vasodilator agents. Cerebral vasodilators; Vertebrates: nervous system and sense organs; Vertebrobasilar Insufficiency - drug therapy; Vertebrobasilar Insufficiency - mortality; Stroke; Nervous system diseases; gender; Cardiovascular disease; Basilar artery; basilar artery occlusion; Cerebral disorder; Arterial disease; Vascular disease; acute stroke; Central nervous system disease; thrombolysis; Artery occlusion; Cerebrovascular disease
• ISSN: 0039-2499; 1524-4628; 1524-4628
• DOI: 10.1161/STROKEAHA.110.594036

Background and Purpose— Randomized trials suggested a different benefit of intravenous thrombolysis (IVT) and intra-arterial thrombolysis (IAT) between men and women with anterior circulation stroke because of a worse outcome of women in the control group. Methods— We compared outcome and recanalization in men and women with basilar artery occlusion treated with antithrombotic treatment alone, IVT or combined IVT–IAT, or IAT in the Basilar Artery International Cooperation Study. Results— Overall, 389 male and 226 female patients were analyzed. In the antithrombotic treatment group, 68 of 111 (61%) men and 47 of 70 (67%) women had a poor outcome defined as a modified Rankin Scale score of 4 to 6 (adjusted risk ratio [aRR], 0.96; 95% CI, 0.75 to 1.24), in the IVT/combined IVT–IAT group, 47 of 77 (61%) men and 24 of 43 (56%) women (aRR, 1.19; 95% CI, 0.89 to 1.60), and in the IAT group, 142 of 185 (77%) men and 71 of 102 (70%) women (aRR, 1.01; 95% CI, 0.88 to 1.17). Mortality was not different between men and women in the antithrombotic treatment group (aRR, 0.80; 95% CI, 0.55 to 1.16), the IVT/combined IVT–IAT group (aRR, 1.11; 95% CI, 0.72 to 1.73), or in the IAT group (aRR, 1.01; 95% CI, 0.75 to 1.36). Insufficient recanalization after combined IVT–IAT or IAT was similar in men and women (23% versus 22%; aRR, 0.92; 95% CI, 0.58 to 1.46). Conclusions— In patients with acute basilar artery occlusion, no significant gender differences for outcome and recanalization were observed, regardless of treatment modality.