In vivo hair growth-promoting efficacies of herbal extracts and their cubosomal suspensions

• Published in: Journal of industrial and engineering chemistry (Seoul, Korea) Vol. 19; no. 4; pp. 1331 - 1339
• Main Authors: Seo, Seung Ree, Kang, Gu, Ha, Jeong Wook, Kim, Jin-Chul
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 25.07.2013; 한국공업화학회
• Subjects: Biocompatibility; Biomedical materials; Cubosome; Effectiveness; Ethyl alcohol; Hair; Hair growth promotion; Herbal extracts; In vivo testing; In vivo tests; Monoolein; Surgical implants; 화학공학; Herbal extracts; Monoolein; Hair growth promotion; Cubosome
• ISSN: 1226-086X; 1876-794X
• DOI: 10.1016/j.jiec.2012.12.037

In vivo hair growth-promoting efficacies of 6 kinds of herbal extracts (obtained from Poria cocos, Thuja orientalis, Espinosilla, Lycium chinense Mill, Coix lacryma-jobi and Polygonum multiflorum Thunberg) and monoolein cubosomal suspensions containing the extracts were investigated after they were daily applied on the backs of C57BL/6 male mice for 20 days in the herbal extract concentration of 3% and the cubosome concentration of 1%. The hair growth-promoting efficacies were evaluated 0 day, 10 days, 15 days, and 20 days after the application through the hair re-growth area and the histological observation of hair follicles. Among them, Thuja orientalis extract, Polygonum multiflorum Thunberg extract, and Espinosilla extract showed some hair-growth promoting efficacy. Cubosomes significantly enhanced the efficacies of the herbal extracts, and the cubosomal suspensions containing the extracts were as potent as Minoxidil solution (2.4%) in propylene glycol/water/ethanol (20/30/50, v/v/v). Cubosome is believed to enhance the skin permeation of the herbal extracts.