Ocular Surface Expression of SARS-CoV-2 Receptors

The spike proteins of SARS-CoV-2 interact with ACE2 or basigin/CD147 receptors, regulating human-to-human transmissions of COVID-19 together with serine protease TMPRSS2. The expression of these receptors on the ocular surface is unknown. Gene expression of SARS-CoV-2 receptors was investigated in c...

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Published inOcular immunology and inflammation Vol. 28; no. 5; pp. 735 - 738
Main Authors Leonardi, Andrea, Rosani, Umberto, Brun, Paola
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 03.07.2020
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ISSN0927-3948
1744-5078
1744-5078
DOI10.1080/09273948.2020.1772314

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Summary:The spike proteins of SARS-CoV-2 interact with ACE2 or basigin/CD147 receptors, regulating human-to-human transmissions of COVID-19 together with serine protease TMPRSS2. The expression of these receptors on the ocular surface is unknown. Gene expression of SARS-CoV-2 receptors was investigated in conjunctival epithelial cell samples and in ex-vivo cornea samples using microarray or transcriptome sequencing. ACE2 is expressed in conjunctival samples at a low level, while BSG and TMPRSS2 are expressed at intermediate levels in both conjunctiva and cornea. Other receptors such as ANPEP, AGTR2 are expressed at low level in the conjunctiva. Two RNA editing enzymes involved in antiviral responses, APOBEC3A, and ADAR-1 were also highly expressed. The ocular surface may represent an entry point for the SARS-CoV-2 in the human body. The conjunctiva and the cornea can adopt antiviral countermeasures which may explain the low prevalence of eye involvement.
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ISSN:0927-3948
1744-5078
1744-5078
DOI:10.1080/09273948.2020.1772314