Increased Prevalence of Barrett's Esophagus in Taiwan: A Prospective Multicenter Study

• Published in: Journal of gastroenterology and hepatology Vol. 40; no. 7; pp. 1695 - 1702
• Main Authors: Lee, Fu‐Jen, Tsai, Ming‐Chang, Chen, Chien‐Lin, Wong, Ming‐Wun, Yen, Hsu‐Heng, Wu, Jeng‐Yih, Chung, Chen‐Shuan, Tseng, Ping‐Huei, Tsai, Ying‐Nan, Hsieh, Ming‐Tsung, Chang, Chi‐Yang
• Format: Journal Article
• Language: English
• Published: Australia Wiley Subscription Services, Inc 01.07.2025; John Wiley and Sons Inc
• Subjects: Adenocarcinoma; Adult; Age Factors; Aged; Aged, 80 and over; Alcohol Drinking - adverse effects; Alcohol Drinking - epidemiology; Barrett Esophagus - epidemiology; Barrett Esophagus - etiology; Barrett Esophagus - pathology; Barrett's esophagus; Biopsy; Endoscopy; Esophagitis; Esophagus; Female; Gastroesophageal reflux; Gastroesophageal Reflux - complications; Gastroesophageal Reflux - epidemiology; Gender; Hernia; Hernia, Hiatal - complications; Hernia, Hiatal - epidemiology; Humans; Male; Metaplasia; Middle Aged; Multivariate Analysis; Original ‐ Gastroenterology (Clinical); Prevalence; Prospective Studies; Risk Factors; Sex Factors; Taiwan - epidemiology; Taiwan; prevalence; hiatal hernia; gastroesophageal reflux disease; risk factor; Barrett's esophagus
• ISSN: 0815-9319; 1440-1746; 1440-1746
• DOI: 10.1111/jgh.16992

With rising rates of esophageal adenocarcinoma (EAC) in Western countries, Barrett's esophagus (BE) has become a growing concern. The increasing prevalence of chronic gastroesophageal reflux disease (GERD) in Taiwan suggests a potential rise in BE cases as well. A 2007 large-scale study reported a BE prevalence of 1.06% in Taiwan. Our multicenter prospective study aims to evaluate the current prevalence of BE and identify key risk factors in this region. We assessed outpatients undergoing upper gastrointestinal endoscopy for various symptoms, obtaining biopsies from endoscopically suspected esophageal metaplasia (ESEM) at least 1 cm above the gastroesophageal junction. Quadrant biopsies were taken every 2 cm, with BE confirmed by histological evidence of specialized intestinal metaplasia. Among 8697 subjects, the prevalence of BE was 2.6%. GERD symptoms, erosive esophagitis (EE), and hiatal hernia (HH) were present in 52.5%, 27.3%, and 7.85% of subjects, respectively. Of 751 with ESEM, 228 were diagnosed with BE, predominantly short-segment BE (78.1%). Multivariate analysis identified significant risk factors for BE: age > 50 (OR = 1.59), male gender (OR = 2.27), alcohol consumption (OR = 1.70), GERD symptoms (OR = 1.45), EE (OR = 1.94), and HH (OR = 2.49) (all p < 0.01). The prevalence of BE was identified as 2.6%, representing a significant increase compared with 2007. Significant risk factors include age more than 50, male gender, alcohol use, GERD symptoms, EE, and HH.