HIV-DNA in rectal cells is well correlated with HIV-DNA in blood in different groups of patients, including long-term non-progressors
Most of the body's lymphoid tissue is in gut and constitutes an immense HIV reservoir. We quantified HIV-DNA in rectum and compared it with blood levels for 27 HIV-infected adults from different groups. We observed a large range of rectal and blood HIV-DNA levels. They were positively correlate...
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| Published in | AIDS (London) Vol. 22; no. 14; pp. 1880 - 1882 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hagerstown, MD
Lippincott Williams & Wilkins
12.09.2008
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0269-9370 1473-5571 1473-5571 |
| DOI | 10.1097/QAD.0b013e32830fbdbc |
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| Abstract | Most of the body's lymphoid tissue is in gut and constitutes an immense HIV reservoir. We quantified HIV-DNA in rectum and compared it with blood levels for 27 HIV-infected adults from different groups. We observed a large range of rectal and blood HIV-DNA levels. They were positively correlated (r = 0.841, P<0.0001). Long-term nonprogressors and patients in 'remission' after antiretroviral treatment interruption had the lowest blood and mucosal HIV-DNA levels. |
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| AbstractList | Most of the body's lymphoid tissue is in gut and constitutes an immense HIV reservoir. We quantified HIV-DNA in rectum and compared it with blood levels for 27 HIV-infected adults from different groups. We observed a large range of rectal and blood HIV-DNA levels. They were positively correlated (r = 0.841, P<0.0001). Long-term nonprogressors and patients in 'remission' after antiretroviral treatment interruption had the lowest blood and mucosal HIV-DNA levels.Most of the body's lymphoid tissue is in gut and constitutes an immense HIV reservoir. We quantified HIV-DNA in rectum and compared it with blood levels for 27 HIV-infected adults from different groups. We observed a large range of rectal and blood HIV-DNA levels. They were positively correlated (r = 0.841, P<0.0001). Long-term nonprogressors and patients in 'remission' after antiretroviral treatment interruption had the lowest blood and mucosal HIV-DNA levels. Most of the body's lymphoid tissue is in gut and constitutes an immense HIV reservoir. We quantified HIV-DNA in rectum and compared it with blood levels for 27 HIV-infected adults from different groups. We observed a large range of rectal and blood HIV-DNA levels. They were positively correlated (r = 0.841, P<0.0001). Long-term nonprogressors and patients in 'remission' after antiretroviral treatment interruption had the lowest blood and mucosal HIV-DNA levels. Most of the body's lymphoid tissue is in gut and constitutes an immense HIV reservoir. We quantified HIV-DNA in rectum and compared it with blood levels for 27 HIV-infected adults from different groups. We observed a large range of rectal and blood HIV-DNA levels. They were positively correlated (r= 0.841, P< 0.0001). Long-term non-progressors and patients in 'remission' after anti-retroviral treatment interruption had the lowest blood and mucosal HIV-DNA levels. |
| Author | Melard, Adeline Kerdraon, Rémy Michau, Christophe Avettand-Fenoel, Véronique Agoute, Eric Hocqueloux, Laurent Rouzioux, Christine Prazuck, Thierry |
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| Keywords | Human Immunopathology Retroviridae AIDS Asymptomatic Immune deficiency Lentivirus Long term Infection Virus Blood group Viral disease DNA Rectum Human immunodeficiency virus |
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| References_xml | – volume: 200 start-page: 749 year: 2004 ident: R6-25-20210130 article-title: CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract publication-title: J Exp Med doi: 10.1084/jem.20040874 – volume: 140 start-page: 222 year: 2007 ident: R11-25-20210130 article-title: Examination of real-time PCR for HIV-1 RNA and DNA quantitation in patients infected with HIV-1 BF intersubtype recombinant variants publication-title: J Virol Methods doi: 10.1016/j.jviromet.2006.11.012 – volume: 200 start-page: 697 year: 2004 ident: R12-25-20210130 article-title: Getting to the guts of HIV pathogenesis publication-title: J Exp Med doi: 10.1084/jem.20041464 – volume: 81 start-page: 599 year: 2007 ident: R7-25-20210130 article-title: Mechanisms of gastrointestinal CD4+ T-cell depletion during acute and early human immunodeficiency virus type 1 infection publication-title: J Virol doi: 10.1128/JVI.01739-06 – volume: 26 start-page: 1 year: 2001 ident: R10-25-20210130 article-title: Virologic and immunologic effect of antiretroviral therapy on HIV-1 in gut-associated lymphoid tissue publication-title: J Acquir Immune Defic Syndr doi: 10.1097/00126334-200101010-00001 – volume: 192 start-page: 46 year: 2005 ident: R1-25-20210130 article-title: Early levels of HIV-1 DNA in peripheral blood mononuclear cells are predictive of disease progression independently of HIV-1 RNA levels and CD4+ T cell counts publication-title: J Infect Dis doi: 10.1086/430610 – volume: 77 start-page: 11708 year: 2003 ident: R8-25-20210130 article-title: Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy publication-title: J Virol doi: 10.1128/JVI.77.21.11708-11717.2003 – volume: 191 start-page: 2053 year: 2005 ident: R2-25-20210130 article-title: Combination of HIV-1-specific CD4 Th1 cell responses and IgG2 antibodies is the best predictor for persistence of long-term nonprogression publication-title: J Infect Dis doi: 10.1086/430320 – volume: 17 start-page: 53 year: 2003 ident: R3-25-20210130 article-title: Multiple measures of HIV burden in blood and tissue are correlated with each other but not with clinical parameters in aviremic subjects publication-title: AIDS doi: 10.1097/00002030-200301030-00008 – volume: 197 start-page: 714 year: 2008 ident: R5-25-20210130 article-title: Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy publication-title: J Infect Dis doi: 10.1086/527324 – volume: 102 start-page: 9860 year: 2005 ident: R9-25-20210130 article-title: Gut mucosal T cell responses and gene expression correlate with protection against disease in long-term HIV-1-infected nonprogressors publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0503463102 – volume: 43 start-page: 65 year: 2006 ident: R4-25-20210130 article-title: Lack of decay of HIV-1 in gut-associated lymphoid tissue reservoirs in maximally suppressed individuals publication-title: J Acquir Immune Defic Syndr doi: 10.1097/01.qai.0000230524.71717.14 |
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| SubjectTerms | Acute Disease Adult Biological and medical sciences Chronic Disease Disease Progression DNA, Viral - analysis DNA, Viral - blood Female HIV Infections - genetics HIV Infections - virology HIV Long-Term Survivors HIV-1 - genetics Human immunodeficiency virus Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Intestinal Mucosa - virology Lymphocytes - virology Lymphoid Tissue - virology Male Medical sciences Middle Aged Rectum Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load |
| Title | HIV-DNA in rectal cells is well correlated with HIV-DNA in blood in different groups of patients, including long-term non-progressors |
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