HIV-DNA in rectal cells is well correlated with HIV-DNA in blood in different groups of patients, including long-term non-progressors

• Published in: AIDS (London) Vol. 22; no. 14; pp. 1880 - 1882
• Main Authors: Avettand-Fenoel, Véronique, Prazuck, Thierry, Hocqueloux, Laurent, Melard, Adeline, Michau, Christophe, Kerdraon, Rémy, Agoute, Eric, Rouzioux, Christine
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 12.09.2008
• Subjects: Acute Disease; Adult; Biological and medical sciences; Chronic Disease; Disease Progression; DNA, Viral - analysis; DNA, Viral - blood; Female; HIV Infections - genetics; HIV Infections - virology; HIV Long-Term Survivors; HIV-1 - genetics; Human immunodeficiency virus; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Intestinal Mucosa - virology; Lymphocytes - virology; Lymphoid Tissue - virology; Male; Medical sciences; Middle Aged; Rectum; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral Load; Human; Immunopathology; Retroviridae; AIDS; Asymptomatic; Immune deficiency; Lentivirus; Long term; Infection; Virus; Blood group; Viral disease; DNA; Rectum; Human immunodeficiency virus
• ISSN: 0269-9370; 1473-5571; 1473-5571
• DOI: 10.1097/QAD.0b013e32830fbdbc

Most of the body's lymphoid tissue is in gut and constitutes an immense HIV reservoir. We quantified HIV-DNA in rectum and compared it with blood levels for 27 HIV-infected adults from different groups. We observed a large range of rectal and blood HIV-DNA levels. They were positively correlated (r = 0.841, P<0.0001). Long-term nonprogressors and patients in 'remission' after antiretroviral treatment interruption had the lowest blood and mucosal HIV-DNA levels.