Association between the FABP2 Ala54Thr and CRP+1059C/G polymorphisms and small dense LDL level in patients with atherosclerosis: a case-control study

• Published in: Archives of physiology and biochemistry Vol. 129; no. 1; pp. 246 - 252
• Main Authors: Yalameha, Banafsheh, Birjandi, Mehdi, Nouryazdan, Negar, Nasri, Hamid, Shahsavari, Gholamreza
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.01.2023
• Subjects: Atherosclerosis; Atherosclerosis - genetics; C-reactive protein; C-Reactive Protein - genetics; Case-Control Studies; fatty acid-binding protein 2; Fatty Acid-Binding Proteins - genetics; Humans; Polymorphism, Genetic; small dense-LDL; C-reactive protein; fatty acid-binding protein 2; Atherosclerosis; small dense-LDL
• ISSN: 1381-3455; 1744-4160; 1744-4160
• DOI: 10.1080/13813455.2020.1817097

The polymorphisms of fatty acid-binding protein 2 (FABP2) and C-reactive protein (CRP) might act as genetic risk factors for atherosclerosis. The study aimed to investigate the relationship between FABP2 Ala54Thr and CRP+1059C/G polymorphisms and atherosclerosis as well as the association of Small dense-LDL (sd-LDL). A total of 255 subjects (125 controls and 130 patients) were included. The FABP2 and CRP polymorphisms were determined by PCR-RFLP and AS-PCR methods, respectively. Sd-LDL was measured based on Hirano et al method. There were no significant distinctions between the patient and control groups concerning FABP2 and CRP polymorphisms (p > .05). No significant relationship was observed between studied polymorphisms and sd-LDL level in the patient group (p > .05). However, patients group had higher level of sd-LDL compared to controls (p < .05). FABP2 Ala54Thr and CRP+1059G/C polymorphisms were not associated with atherosclerosis and sd-LDL level. However, the increased sd-LDL level was known as a risk factor for atherosclerosis.