Bio-interfacial magnetic resonance imaging of hyperpolarized contrast agents for metabolic flux interrogation in vivo

We utilized dynamic nuclear polarization to hyperpolarize three metabolic imaging agents as single agents and together (co-polarization with two different organic radicals; OX63 and BDPA). In addition, we describe our initial two slice selective spectroscopy in vivo experiments in mice. These techni...

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Published inJournal of industrial and engineering chemistry (Seoul, Korea) Vol. 36; pp. 224 - 228
Main Authors Jeong, Gijin, Lee, Jee-Wook, Gong, Gyeonghyeon, Ko, Hyeji, Choi, Ikjang, Seo, Hyeonglim, Lee, Youngbok, Millward, Niki M. Zacharias, Bhattacharya, Pratip K.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 25.04.2016
한국공업화학회
Subjects
Contrast agents
Dynamic nuclear polarization
Flux
Hyperpolarization
In vivo metabolic MR
In vivo methods and tests
Interrogation
MR spectroscopy and imaging
Polarization
Radicals
Real time
Spectroscopy
화학공학
Dynamic nuclear polarization
In vivo metabolic MR
MR spectroscopy and imaging
Hyperpolarization
Online AccessGet full text
ISSN1226-086X
1876-794X
DOI10.1016/j.jiec.2016.02.002

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Summary:We utilized dynamic nuclear polarization to hyperpolarize three metabolic imaging agents as single agents and together (co-polarization with two different organic radicals; OX63 and BDPA). In addition, we describe our initial two slice selective spectroscopy in vivo experiments in mice. These techniques along with advances by other laboratories will allow for multiple metabolic pathways to be imaged in real-time and in vivo.
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G704-000711.2016.36..009
ISSN:1226-086X
1876-794X
DOI:10.1016/j.jiec.2016.02.002