Evaluation of cardiovascular disease risk in women with surgically induced menopause

• Published in: Gynecological endocrinology Vol. 32; no. 6; pp. 498 - 501
• Main Authors: Sari, Nagihan, Engin-Üstün, Yaprak, Kiyak Çağlayan, Emel, Göçmen, Ayşe Yeşim, Polat, Muhammet Fevzi
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.06.2016
• Subjects: Biomarkers - blood; C-Reactive Protein - metabolism; Cardiovascular Diseases - blood; Cardiovascular risk; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Female; Fibrinogen - metabolism; Growth Differentiation Factor 15 - blood; Humans; Hysterectomy - adverse effects; Menopause - blood; Menopause, Premature - blood; Middle Aged; Natriuretic Peptide, Brain - blood; natural menopause; Ovariectomy - adverse effects; Risk; Serum Albumin; Serum Albumin, Human; surgical menopause; Triglycerides - blood; surgical menopause; natural menopause; Cardiovascular risk
• ISSN: 0951-3590; 1473-0766; 1473-0766
• DOI: 10.3109/09513590.2015.1136615

Objective: This study evaluates cardiovascular disease (CVD) risk among women undergoing natural menopause or surgically induced menopause through the measurement of serum growth differentiation factor-15 (GDF-15), B-type natriuretic peptide (BNP), ischemia modified albumin (IMA), total cholesterol, LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), triglyceride, fibrinogen, and C-reactive protein (CRP). Materials and methods: The study included women with surgically induced menopause (n = 50) and women undergoing natural menopause (n = 50). The two study groups were matched according to age, body mass index, menopause duration. GDF-15, BNP, IMA, total cholesterol, LDL-C, HDL-C, triglyceride, fibrinogen, and CRP were measured. Results: There was no significant difference in GDF-15, BNP, IMA, total cholesterol, LDL-C, HDL-C, triglyceride, fibrinogen, and CRP results between the two groups. Conclusion: We conclude that there is no increase in CVD risk among women aged 40-50 with surgically induced menopause relative to matched control subjects undergoing normal age-related menopause.