The Association of Acute Cerebrospinal Fluid Pressure Reduction with Choroidal Thickness

• Published in: Current eye research Vol. 46; no. 8; pp. 1193 - 1200
• Main Authors: Liu, Xiangxiang, Khodeiry, Mohamed M., Lin, Danting, Sun, Yunxiao, Lin, Caixia, Feng, Wei, Li, Jing, Wang, Yaxing, Zhang, Qing, Cao, Kai, Wang, Jiawei, Wang, Ningli
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.08.2021
• Subjects: Acute Disease; Adult; Blood Pressure - physiology; Cerebrospinal fluid pressure; Cerebrospinal Fluid Pressure - physiology; Choroid - blood supply; Choroid - diagnostic imaging; Choroid - pathology; choroidal thickness; Ciliary Arteries - physiology; Female; Humans; Male; Middle Aged; Prospective Studies; Slit Lamp Microscopy; small to medium vessel layer; Spinal Puncture; Tomography, Optical Coherence; Visual Acuity - physiology; choroidal thickness; small to medium vessel layer; Cerebrospinal fluid pressure
• ISSN: 0271-3683; 1460-2202; 1460-2202
• DOI: 10.1080/02713683.2021.1874024

To investigate the changes in choroidal thickness (CT) after acute cerebrospinal fluid pressure (CSFP) reduction in human subjects. Before and 15 minutes after diagnostic lumbar puncture (LP), 44 patients underwent measurement of CT by swept-source optical coherence tomography. Thirty-two healthy volunteers imitated the body posture of LP procedure and underwent the same measurement before and 15 minutes after body posture change. After CSFP reduction from 10.9 ± 2.1 mmHg at baseline to 8.1 ± 1.5 mmHg (p < 0.001), CT decreased in subfoveal region (p = 0.005), small to medium vessel layer (SMVL, p < 0.001), peripapillary regions in temporal (p = 0.001), nasal (p < 0.001), superior (p < 0.001) and inferior (p < 0.001), respectively. However, no significant change in CT in the control group after body posture change (all p > 0.05). A significant association between CSFP and the ratio of small to medium vessel layer to total choroidal thickness was found (p = 0.009). The CSFP reduction rate was associated with the change rate of SMVL to total CT portion, for each percent decrease in CSFP was associated with a decrease by 0.22% in the rate of SMVL to total CT portion (R 2  = 0.125, p = 0.018). A significant decrease in subfoveal CT, small to medium vessel layer and peripapillary region were observed following acute CSFP reduction. The CSFP reduction rate was associated with the change rate of small to medium vessel layer to total CT portion.