Urinary Excretion Rate of Furosemide and Diuretic Response in Man

Adaptation was attempted of the concentration-response equations proposed by Wagner to the pharmacokinetic and pharmacodynamic data obtained after oral administration of furosemide to healthy human subjects. The results revealed that a quantitative correlation between drug concentration and pharmaco...

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Published inYAKUGAKU ZASSHI Vol. 106; no. 7; pp. 590 - 593
Main Authors KATAYAMA, KAZUNORI, KAKEMI, MASAWO, ZHU, JIABI, KOIZUMI, TAMOTSU
Format Journal Article
LanguageJapanese
Published Japan The Pharmaceutical Society of Japan 01.07.1986
Subjects
concentration-response relationship
Diuresis - drug effects
diuretic response
diuretics
furosemide
Furosemide - metabolism
Furosemide - pharmacology
Humans
Kinetics
pharmacologic response
Online AccessGet full text
ISSN0031-6903
1347-5231
DOI10.1248/yakushi1947.106.7_590

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Abstract Adaptation was attempted of the concentration-response equations proposed by Wagner to the pharmacokinetic and pharmacodynamic data obtained after oral administration of furosemide to healthy human subjects. The results revealed that a quantitative correlation between drug concentration and pharmacologic response decreases with the cumulation of diuretic response or cumulated urine volume.
AbstractList Adaptation was attempted of the concentration-response equations proposed by Wagner to the pharmacokinetic and pharmacodynamic data obtained after oral administration of furosemide to healthy human subjects. The results revealed that a quantitative correlation between drug concentration and pharmacologic response decreases with the cumulation of diuretic response or cumulated urine volume.
Author ZHU, JIABI
KAKEMI, MASAWO
KATAYAMA, KAZUNORI
KOIZUMI, TAMOTSU
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  fullname: KOIZUMI, TAMOTSU
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References 1) 現住所: 中華人民共和国, 南京葯学院, 満剤学教研室.
2) 朱家壁, 片山和憲, 掛見正郎, 小泉保, 薬誌, 106, 221 (1986).
6) 朱家壁, 小泉保, 薬誌, 102, 352 (1982).
4) T. Arita, R. Hori, E. Owada, K. Takahashi, Chem. Pharm. Bull., 17, 2526 (1969).
5) 中村慶一 (訳), “応用回帰分析, ” 森北出版, 東京, 1967, pp.8-14.
3) J.G. Wagner, “Fundamentals of Clinical Pharmacokinetics,” Drug Intelligence Publications, Hamilton, 1975, pp.307-336.
7) 成実清松, 坂井忠次, “数理統計学要説, ” 培風館, 東京, 1955, pp.132-133.
References_xml – reference: 1) 現住所: 中華人民共和国, 南京葯学院, 満剤学教研室.
– reference: 3) J.G. Wagner, “Fundamentals of Clinical Pharmacokinetics,” Drug Intelligence Publications, Hamilton, 1975, pp.307-336.
– reference: 4) T. Arita, R. Hori, E. Owada, K. Takahashi, Chem. Pharm. Bull., 17, 2526 (1969).
– reference: 6) 朱家壁, 小泉保, 薬誌, 102, 352 (1982).
– reference: 5) 中村慶一 (訳), “応用回帰分析, ” 森北出版, 東京, 1967, pp.8-14.
– reference: 2) 朱家壁, 片山和憲, 掛見正郎, 小泉保, 薬誌, 106, 221 (1986).
– reference: 7) 成実清松, 坂井忠次, “数理統計学要説, ” 培風館, 東京, 1955, pp.132-133.
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SubjectTerms concentration-response relationship
Diuresis - drug effects
diuretic response
diuretics
furosemide
Furosemide - metabolism
Furosemide - pharmacology
Humans
Kinetics
pharmacologic response
Title Urinary Excretion Rate of Furosemide and Diuretic Response in Man
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