Urinary Excretion Rate of Furosemide and Diuretic Response in Man

Adaptation was attempted of the concentration-response equations proposed by Wagner to the pharmacokinetic and pharmacodynamic data obtained after oral administration of furosemide to healthy human subjects. The results revealed that a quantitative correlation between drug concentration and pharmaco...

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Published inYAKUGAKU ZASSHI Vol. 106; no. 7; pp. 590 - 593
Main Authors KATAYAMA, KAZUNORI, KAKEMI, MASAWO, ZHU, JIABI, KOIZUMI, TAMOTSU
Format Journal Article
LanguageJapanese
Published Japan The Pharmaceutical Society of Japan 01.07.1986
Subjects
concentration-response relationship
Diuresis - drug effects
diuretic response
diuretics
furosemide
Furosemide - metabolism
Furosemide - pharmacology
Humans
Kinetics
pharmacologic response
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ISSN0031-6903
1347-5231
DOI10.1248/yakushi1947.106.7_590

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Summary:Adaptation was attempted of the concentration-response equations proposed by Wagner to the pharmacokinetic and pharmacodynamic data obtained after oral administration of furosemide to healthy human subjects. The results revealed that a quantitative correlation between drug concentration and pharmacologic response decreases with the cumulation of diuretic response or cumulated urine volume.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0031-6903
1347-5231
DOI:10.1248/yakushi1947.106.7_590