Furan fatty acids – Beneficial or harmful to health?

• Published in: Progress in lipid research Vol. 68; pp. 119 - 137
• Main Authors: Xu, Long, Sinclair, Andrew J., Faiza, Muniba, Li, Daoming, Han, Xianlin, Yin, Huiyong, Wang, Yonghua
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2017
• Subjects: 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid; Diabetes Mellitus - metabolism; Fatty Acids - biosynthesis; Fatty Acids - chemistry; Fatty Acids - metabolism; Furan fatty acids; Furans - chemistry; Health; Humans; Metabolism; Renal failure; Renal Insufficiency - metabolism; Type 2 diabetes; Type 2 diabetes; OAT; LC/MS/MS; HK-2 cells; Furan fatty acids; T2D(M); FT-IR; 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid; AGEs; Metabolism; SRM-MS; GDM; TGF; Renal failure; IGT; CMPentylF; NGT; TAG; LC/ESI-MS/MS; CMPF; ELISA; LC-MS-MS
• ISSN: 0163-7827; 1873-2194; 1873-2194
• DOI: 10.1016/j.plipres.2017.10.002

Furan fatty acids are found in plants, algae, and fish, and reported to have some positive health benefits, including anti-oxidant and anti-inflammatory activities, and inhibition of non-enzymatic lipid peroxidation. A major metabolite of furan fatty acids, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), has been reported to be increased in patients who progress from prediabetes to type 2 diabetes, although CMPF is not necessarily associated with impaired glucose metabolism. Other studies report that CMPF levels are lower in subjects with diabetes than control subjects. Plasma CMPF levels increase in subjects who consume fish or fish oil, and in patients with renal failure. It is not known where furan fatty acids are converted to CMPF and it is speculated that this might be a result of microbiome activity. The plasma levels reported for CMPF in healthy, diabetic and patients with renal disease vary by factors of more than 100-fold within each of these three groups, so measurement error appears to be limiting the ability to interpret studies. This review explores these controversies and raises questions about whether CMPF is a marker for healthy diets or indeed associated with diabetes and renal health. The review concludes that, on balance, furan fatty acids are beneficial for health.