AI-based non-invasive imaging technologies for early autism spectrum disorder diagnosis: A short review and future directions

Autism Spectrum Disorder (ASD) is a neurological condition, with recent statistics from the CDC indicating a rising prevalence of ASD diagnoses among infants and children. This trend emphasizes the critical importance of early detection, as timely diagnosis facilitates early intervention and enhance...

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Published inArtificial intelligence in medicine Vol. 161; p. 103074
Main Authors Abdelrahim, Mostafa, Khudri, Mohamed, Elnakib, Ahmed, Shehata, Mohamed, Weafer, Kate, Khalil, Ashraf, Saleh, Gehad A., Batouty, Nihal M., Ghazal, Mohammed, Contractor, Sohail, Barnes, Gregory, El-Baz, Ayman
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.03.2025
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Online AccessGet full text
ISSN0933-3657
1873-2860
1873-2860
DOI10.1016/j.artmed.2025.103074

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Abstract Autism Spectrum Disorder (ASD) is a neurological condition, with recent statistics from the CDC indicating a rising prevalence of ASD diagnoses among infants and children. This trend emphasizes the critical importance of early detection, as timely diagnosis facilitates early intervention and enhances treatment outcomes. Consequently, there is an increasing urgency for research to develop innovative tools capable of accurately and objectively identifying ASD in its earliest stages. This paper offers a short overview of recent advancements in non-invasive technology for early ASD diagnosis, focusing on an imaging modality, structural MRI technique, which has shown promising results in early ASD diagnosis. This brief review aims to address several key questions: (i) Which imaging radiomics are associated with ASD? (ii) Is the parcellation step of the brain cortex necessary to improve the diagnostic accuracy of ASD? (iii) What databases are available to researchers interested in developing non-invasive technology for ASD? (iv) How can artificial intelligence tools contribute to improving the diagnostic accuracy of ASD? Finally, our review will highlight future trends in ASD diagnostic efforts.
AbstractList Autism Spectrum Disorder (ASD) is a neurological condition, with recent statistics from the CDC indicating a rising prevalence of ASD diagnoses among infants and children. This trend emphasizes the critical importance of early detection, as timely diagnosis facilitates early intervention and enhances treatment outcomes. Consequently, there is an increasing urgency for research to develop innovative tools capable of accurately and objectively identifying ASD in its earliest stages. This paper offers a short overview of recent advancements in non-invasive technology for early ASD diagnosis, focusing on an imaging modality, structural MRI technique, which has shown promising results in early ASD diagnosis. This brief review aims to address several key questions: (i) Which imaging radiomics are associated with ASD? (ii) Is the parcellation step of the brain cortex necessary to improve the diagnostic accuracy of ASD? (iii) What databases are available to researchers interested in developing non-invasive technology for ASD? (iv) How can artificial intelligence tools contribute to improving the diagnostic accuracy of ASD? Finally, our review will highlight future trends in ASD diagnostic efforts.Autism Spectrum Disorder (ASD) is a neurological condition, with recent statistics from the CDC indicating a rising prevalence of ASD diagnoses among infants and children. This trend emphasizes the critical importance of early detection, as timely diagnosis facilitates early intervention and enhances treatment outcomes. Consequently, there is an increasing urgency for research to develop innovative tools capable of accurately and objectively identifying ASD in its earliest stages. This paper offers a short overview of recent advancements in non-invasive technology for early ASD diagnosis, focusing on an imaging modality, structural MRI technique, which has shown promising results in early ASD diagnosis. This brief review aims to address several key questions: (i) Which imaging radiomics are associated with ASD? (ii) Is the parcellation step of the brain cortex necessary to improve the diagnostic accuracy of ASD? (iii) What databases are available to researchers interested in developing non-invasive technology for ASD? (iv) How can artificial intelligence tools contribute to improving the diagnostic accuracy of ASD? Finally, our review will highlight future trends in ASD diagnostic efforts.
Autism Spectrum Disorder (ASD) is a neurological condition, with recent statistics from the CDC indicating a rising prevalence of ASD diagnoses among infants and children. This trend emphasizes the critical importance of early detection, as timely diagnosis facilitates early intervention and enhances treatment outcomes. Consequently, there is an increasing urgency for research to develop innovative tools capable of accurately and objectively identifying ASD in its earliest stages. This paper offers a short overview of recent advancements in non-invasive technology for early ASD diagnosis, focusing on an imaging modality, structural MRI technique, which has shown promising results in early ASD diagnosis. This brief review aims to address several key questions: (i) Which imaging radiomics are associated with ASD? (ii) Is the parcellation step of the brain cortex necessary to improve the diagnostic accuracy of ASD? (iii) What databases are available to researchers interested in developing non-invasive technology for ASD? (iv) How can artificial intelligence tools contribute to improving the diagnostic accuracy of ASD? Finally, our review will highlight future trends in ASD diagnostic efforts.
ArticleNumber 103074
Author Shehata, Mohamed
Saleh, Gehad A.
Barnes, Gregory
Weafer, Kate
Khudri, Mohamed
Elnakib, Ahmed
Abdelrahim, Mostafa
Batouty, Nihal M.
El-Baz, Ayman
Contractor, Sohail
Khalil, Ashraf
Ghazal, Mohammed
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  email: ayman.elbaz@louisville.edu
  organization: Bioengineering Department, University of Louisville, Louisville, KY 40292, USA
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Keywords Diagnosis
sMRI
Artificial Intelligence
Autism spectrum disorder
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Snippet Autism Spectrum Disorder (ASD) is a neurological condition, with recent statistics from the CDC indicating a rising prevalence of ASD diagnoses among infants...
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StartPage 103074
SubjectTerms Artificial Intelligence
Autism spectrum disorder
Autism Spectrum Disorder - diagnosis
Autism Spectrum Disorder - diagnostic imaging
Brain - diagnostic imaging
Child
Diagnosis
Early Diagnosis
Humans
Magnetic Resonance Imaging - methods
Neuroimaging - methods
sMRI
Title AI-based non-invasive imaging technologies for early autism spectrum disorder diagnosis: A short review and future directions
URI https://www.clinicalkey.com/#!/content/1-s2.0-S0933365725000090
https://dx.doi.org/10.1016/j.artmed.2025.103074
https://www.ncbi.nlm.nih.gov/pubmed/39919468
https://www.proquest.com/docview/3164654866
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