The development of hepatocellular carcinoma during long-term treatment for recurrent non-small cell lung cancer: a case report

• Published in: Journal of liver cancer Vol. 23; no. 1; pp. 230 - 234
• Main Author: Kang, Seong Hee
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Liver Cancer Association 01.03.2023; Korean Liver Cancer Association; 대한간암학회
• Subjects: Case Report; hepatocellular; lung neoplasms; neoplasms; second primary; carcinoma; 의학일반; second primary; Carcinoma; hepatocellular; Lung neoplasms; Neoplasms
• ISSN: 2288-8128; 2383-5001; 2383-5001
• DOI: 10.17998/jlc.2023.03.03

Multiple primary malignancies (MPMs) are defined as the presence of two or more malignancies in different organs, without a subordinate relationship. Although rarely reported, hepatocellular carcinoma (HCC) occasionally presents with simultaneous or metachronous primary malignancies in other organs. In this report, we describe a patient with lung adenocarcinoma and lymph node and bone metastases, treated with five chemotherapeutic regimens for 24 months. Changing the chemotherapy regimen based on the suspicion of metastasis of a new liver mass did not lead to improvements. This prompted a liver biopsy and a revised diagnosis of HCC. Sixth-line treatment with the concurrent use of cisplatin-paclitaxel for lung cancer and sorafenib for HCC, stabilized the disease. The concurrent treatment was not tolerated and was discontinued owing to adverse events. Considering our findings, treatment with increased efficacy and lower toxicity for MPMs is warranted.