An insight into medicinal attributes of dithiocarbamates: Bird’s eye view

• Published in: Bioorganic chemistry Vol. 105; p. 104346
• Main Authors: Shinde, Sangita Dattatray, Sakla, Akash P., Shankaraiah, Nagula
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2020
• Subjects: Animals; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Anticancer; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antitubercular Agents - chemistry; Antitubercular Agents - pharmacology; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Biological Products - chemistry; Biological Products - pharmacology; Carbonic Anhydrases - metabolism; Chemistry, Pharmaceutical; Cholinergic Antagonists - chemistry; Cholinergic Antagonists - pharmacology; Coordination Complexes - chemistry; Dithiocarbamate; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; Histone Deacetylases - metabolism; Histone Demethylases - antagonists & inhibitors; Humans; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - pharmacology; Metal complex; Molecular Structure; Multicomponent reaction; Natural products; Protein Kinases - metabolism; Thiocarbamates - chemistry; Thiocarbamates - pharmacology; STD; PAS; PBDs; AHL; SAR; ACh; PDTC; NOTA; NDM-1; Aβ; MTZ; BuChE; MBL; LSD1; CA; PDK1; WHO; Multicomponent reaction; AD; MK-2; PLK1; Metal complex; DMBA; PPARγ; TB; CYP51; ECAR; ARA; FAK; DTC; DES; PEG; CAS; MEM; Natural products; CAIs; ROS; BTK; Dithiocarbamate; MAO; PK; Anticancer; DHA; hAChE; HDAC
• ISSN: 0045-2068; 1090-2120; 1090-2120
• DOI: 10.1016/j.bioorg.2020.104346

[Display omitted] •Dithiocarbamates as an important structural motif with potential biological functions.•Description on general synthetic approaches to access dithiocarbamates.•Plausible mode of action and therapeutic targets.•Focus on structure–activity relationship. Dithiocarbamates are considered as an important motif owing to its extensive biological applications in medicinal chemistry. The synthesis of this framework can easily be achieved via a one-pot reaction of primary/secondary amines, CS2, and alkyl halides under catalyst-free conditions or sometimes in the presence of a base. By virtue of its colossal pharmacological scope, it has been an evolving subject of interest for many researchers around the world. The present review aims to highlight various synthetic approaches for dithiocarbamates with the major emphasis on medicinal attributes of these architectures as leads in the drug discovery of small molecules such as HDAC inhibitor, lysine-specific demethylase 1 (LSD1) down-regulator, kinase inhibitor (focal adhesion kinase, pyruvate kinase, Bruton’s tyrosine kinase), carbonic anhydrase inhibitor, DNA intercalators, and apoptosis-inducing agents. Moreover, recent medicinal advancements in the synthesis of dithiocarbamate derivatives as anticancer, antifungal, antibacterial, anti-Alzheimer, antitubercular, anti-glaucoma, anti-cholinergic, antihyperglycemic, anti-inflammatory activities have been elaborated with notable examples.