Bladder base/trigone injection is safe and as effective as bladder body injection of onabotulinumtoxinA for idiopathic detrusor overactivity refractory to antimuscarinics

• Published in: Neurourology and urodynamics Vol. 30; no. 7; pp. 1242 - 1248
• Main Author: Kuo, Hann-Chorng
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2011
• Subjects: Administration, Intravesical; Adult; Aged; Aged, 80 and over; Analysis of Variance; Botulinum Toxins, Type A - administration & dosage; Botulinum Toxins, Type A - adverse effects; Chi-Square Distribution; detrusor overactivity; Female; Humans; intravesical therapy; Kaplan-Meier Estimate; Male; Middle Aged; Muscarinic Antagonists - therapeutic use; Neuromuscular Agents - administration & dosage; Neuromuscular Agents - adverse effects; overactive bladder; Severity of Illness Index; Single-Blind Method; Taiwan; Time Factors; Treatment Failure; Urinary Bladder - drug effects; Urinary Bladder - innervation; Urinary Bladder, Overactive - diagnosis; Urinary Bladder, Overactive - drug therapy; Urinary Bladder, Overactive - physiopathology; urodynamics; Urodynamics - drug effects; Young Adult
• ISSN: 0733-2467; 1520-6777; 1520-6777
• DOI: 10.1002/nau.21054

Purpose The purpose of this study was to evaluate the efficacy and safety of onabotulinumtoxinA injections at bladder base/trigone and compare with injections at bladder body or bladder body/trigone for the treatment of idiopathic detrusor overactivity (IDO) refractory to antimuscarinics. Materials and Methods A single blind, randomized, paralleled, actively controlled trial was performed in patients with urodynamically proven IDO who failed antimuscarinic therapy. Patients were randomly assigned to receive intravesical injections of 100 U of onabotulinumtoxinA into three different bladder sites. All treatments were evaluated by voiding diary variables, urgency severity score, urodynamic studies, and patient perception of bladder condition. Long‐term success rates over 12 months were also determined. Results Among the patients, 37 were randomized to injections in the bladder body, 35 into the bladder body/trigone, and 33 into the bladder base/trigone. Successful results were reported in 76 (72%) patients at 3 months: 26 (70%) in the bladder body group, 26 (74%) in the bladder body/trigone group, and 24 (73%) in the bladder base/trigone group. There were no significant differences in success rates, changes in urgency and urgency incontinence episodes, urodynamic variables, or long‐term success rates among the three subgroups. The incidence of adverse events was similar among three groups. No vesicoureteral reflux was noted in all patients with or without involving trigone injection. Conclusion Intravesical onabotulinumtoxinA injection is an effective treatment for IDO regardless of the bladder injection site. Bladder base/trigone injection is as safe and effective as bladder body injections with or without trigone involvement. Neurourol. Urodynam. 30:1242–1248, 2011. © 2011 Wiley‐Liss, Inc.