Clinical Study of Gingival Hyperplasia Caused by Diphenylhydantoin

• Published in: Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) Vol. 28; no. 4; pp. 1084 - 1092
• Main Authors: SUZUKI, Rieko, HORIUCHI, Hiroshi, SUZUKI, Yuhei, MAITA, Eikichi
• Format: Journal Article
• Language: Japanese
• Published: Japan JAPANESE SOCIETY OF PERIODONTOLOGY 1986
• Subjects: Adolescent; Adult; Child; Dental Plaque - diagnosis; Diphenylhydantoin; Gingival hyperplasia; Gingival Hyperplasia - chemically induced; Gingival Hyperplasia - diagnosis; Humans; Periodontal Diseases - diagnosis; Phenytoin - adverse effects; Severely disabled patient
• ISSN: 0385-0110; 1880-408X
• DOI: 10.2329/perio.28.1084

Seventy six severely disabled patients taking di-phenylhydantoin (DPH) hospitalized in 2 institute in Miyagi Prefecture were the subjects of this investi-gation. The relationship between the gingival hyperplasia and the DPH dose, as well as periodontal status was estimated. The degree of gingival hyper-plasia was measured using 5 grades of classification of Stern (1943). The group having higher gingival hyperplasia score possessed deeper probing pocket depth (PD) and larger plaque index (P1 I). Any significant relation-ship was not detected between the grade of gingival hyperplasia and the amount of gingival bleeding (bleeding index and salivary occult blood level). Although there were no significant difference in age level, body weight, daily DPH dose and the period of receiving the DPH, higher gingival hyper-plasia group took larger amount of daily DPH dose per unit body weight than the other group.