A new ginsengenin containing an oxacyclopentane-ring isolated from the acid hydrolysate of total ginsenosides

Bioassay-guided fractionation of the acid hydrolysate of total ginsenosides of Panax ginseng C.A.Meyer （Araliaceae） led to the isolation of a novel ginsengenin（1）.The structure of 1 was determined as （20S,22S）-dammar-22,25-epoxy-3β,12β,20-triol by extensive spectroscopy and single-crystal X-ray diff...

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Published inChinese chemical letters Vol. 24; no. 6; pp. 524 - 526
Main Authors Guan, Qing-Xiang, Sun, De-Ya, Liu, Ji-Hua, Li, Wei, Meng, Qin, Geng, Cong, Yin, Jian-Yuan
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.06.2013
School of Pharmacy, Jilin University, Changchun 130021, China%School of Pharmacy, Jilin University, Changchun 130021, China
Beijing Laviana Pharmactech Co., Ltd., Beijing 102206, China
Subjects
A549细胞
Cytotoxicity
Ginsengenin
MTT法
Oxacyclopentane
X-射线衍射分析
人参总皂苷
水解产物
生物活性
细胞毒作用
隔绝
Ginsengenin
Oxacyclopentane
Cytotoxicity
Online AccessGet full text
ISSN1001-8417
1878-5964
DOI10.1016/j.cclet.2013.03.044

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Summary:Bioassay-guided fractionation of the acid hydrolysate of total ginsenosides of Panax ginseng C.A.Meyer （Araliaceae） led to the isolation of a novel ginsengenin（1）.The structure of 1 was determined as （20S,22S）-dammar-22,25-epoxy-3β,12β,20-triol by extensive spectroscopy and single-crystal X-ray diffraction analyses.The cytotoxicity of 1 was further tested against SWl 116,HCTl 16,and A549 cells by the MTT method,with IC50 values in the range of 2.96-30.9μmol/L.
Bibliography:Bioassay-guided fractionation of the acid hydrolysate of total ginsenosides of Panax ginseng C.A.Meyer （Araliaceae） led to the isolation of a novel ginsengenin（1）.The structure of 1 was determined as （20S,22S）-dammar-22,25-epoxy-3β,12β,20-triol by extensive spectroscopy and single-crystal X-ray diffraction analyses.The cytotoxicity of 1 was further tested against SWl 116,HCTl 16,and A549 cells by the MTT method,with IC50 values in the range of 2.96-30.9μmol/L.
11-2710/O6
Ginsengenin Oxacyclopentane Cytotoxicity
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2013.03.044