Application of the wavelet method for the simultaneous quantitative determination of benazepril and hydrochlorothiazide in their mixtures

• Published in: Journal of AOAC International Vol. 87; no. 4; p. 834
• Main Authors: Dinç, Erdal, Baleanu, Dumitru
• Format: Journal Article
• Language: English
• Published: England 01.07.2004
• Subjects: Algorithms; Angiotensin-Converting Enzyme Inhibitors - analysis; Antihypertensive Agents - analysis; Benzazepines - analysis; Calibration; Drug Combinations; Hydrochlorothiazide - analysis; Reference Standards; Regression Analysis; Solutions; Tablets
• ISSN: 1060-3271; 1944-7922
• DOI: 10.1093/jaoac/87.4.834

The discrete and continuous wavelet transforms were applied to the overlapping signal analysis of the ratio data signal for simultaneous quantitative determination of the title subject compounds in samples. The ratio spectra data of the binary mixtures containing benazepril (BE) and hydrochlorothiazide (HCT) were transferred as data vectors into the wavelet domain. Signal compression, followed by a 1-dimension continuous wavelet transform (CWT), was used to obtain coincident transformed signals for pure BE and HCT and their mixtures. The coincident transformed amplitudes corresponding to both maximum and minimum points allowed construction of calibration graphs for each compound in the binary mixture. The validity of CWT calibrations was tested by analyzing synthetic mixtures of the investigated compounds, and successful results were obtained. All calculations were performed within EXCEL, C++, and MATLAB6.5 softwares. The obtained results indicated that our approach was flexible and applicable for the binary mixture analysis.